With the most likely diagnosis of transitional cell cloacogenic carcinoma of the anorectal verge, the patient underwent treatment with gemcitabine and cisplatin administered every 21 days, similar to the traditional treatment for TCC of the bladder [9-12].
The onset of symptoms is often abrupt, with the duration of symptoms for cloacogenic carcinoma being generally shorter in comparison to those for squamous cell anal neoplasms .
One small study of anal cloacogenic carcinoma found that 5FU plus MMC or cisplatin led to three- and five-year survival rates of 71% and 48%, respectively .
Souilliard, "Transitional cloacogenic carcinoma of the anal canal.
12) Because the anorectal transitional zone where cloacogenic tumors arise shares an embryologic origin with the uterine cervix, a site of cancers related to sexual intercourse, the Fox Chase team posed "the serious question of the etiologic potential of receptive anal intercourse in the development of cloacogenic carcinoma.
Cloacogenic carcinoma of the anorectum in homosexual men: an observation of four cases.
INTRODUCTION: Cloacogenic Carcinoma accounts for 2-3% of all anorectal carcinoma found in all age groups but predominantly in 5th to 6th decade.
Cloacogenic carcinoma arise from the mucosa of transitional or cloacogenic zone separating the rectal and anal mucous membranes.
Diagnosis--Features are consistent with cloacogenic carcinoma.
The morphologic patterns that are commonly associated with basaloid or cloacogenic carcinoma include nested and trabecular growth of small cells without the intercellular bridges typical of conventional squamous cell carcinoma (Figure 4), although foci of more conventional squamous differentiation can usually be found.
Histogenesis of cloacogenic carcinoma: fine structure of anal transitional epithelium and cloacogenic carcinoma.
In addition, the possibility of a metastatic cloacogenic carcinoma
of the anus and adenoid cystic/basal cell carcinoma arising in Cowper glands should be also addressed.