had been noticed at birth, but medical attention was only sought at age 13.
2,3] In the 25% raised as female, clitoromegaly
can be present.
Females with 21-hydroxylase deficiency typically have clitoromegaly
due to excess androgen production, so examination of the genitalia is a crucial part of the evaluation of a baby girl with hyponatremia and hyperkalemia.
A thorough diagnosis is important, especially if your levels of testosterone are above 200 ng/dL, or you have symptoms of "virilization" such as facial beard, clitoromegaly
(enlarged clitoris), balding at the temples, deepening voice or muscle enlargement.
There can also be permanent virilizing effects such as male-pattern baldness, deepened voice, hirsutism, and clitoromegaly
Another form of intersexuality is the presence of ambiguous genitalia at birth, including clitoromegaly
, (87) micropenis, (88) or hypospadias.
INCREASED ANDROGEN THE SYMPTOMSAn enlarged clitoris, known as clitoromegaly
, so the sexual organ lookslike a small penis and noticeable heavy hair growth on the body are both signs of excess androgen.
6] suggest that those individuals with bilateral streaks are associated with the phenotype of a sexually infantile female; those with a streak and intra-abdominal testis present with clitoromegaly
in a female; individuals with one scrotal testis and an intra abdominal streak are associated with frank sexual ambiguity and bilateral scrotal testis tends to present as a male with short stature and gonadal failure.
3 nmol/L) 2 SV Adult body odor and increased growth velocity at 5 years; basal 17OHP, 16 946 ng/dL (509 nmol/L) 6 SV Diagnosed at 10 years with significant virilization including clitoromegaly
, hirsutism, muscular habitus, and low voice; bone age, 15 years at chronologic age of 10 years; elevated urinary 17-ketosteroids 7 NC Diagnosed at 28 years with hirsutism, male pattern baldness; basal 17OHP, 740 ng/dL (22 nmol/L); cosyntropin/stimulated 17OHP, 3460 ng/ dL (104 nmol/L); precocious puberty with menarche at age 8 years 7S (c) NC Diagnosed at 62 years secondary to family genetic studies; basal 17OHP, 813 ng/dL (24 nmol/L); cosyntropin/stimulated 17OHP, 7190 ng/ dL (216 nmol/L); menarche at age 9 years (a) 17OHP, 17-hydroxyprogesterone.
Additionally, one needs to be aware that it may be difficult for patients to apply the correct dose of testosterone if using transdermal formulations, and potential irreversible complications of excess testosterone use include voice deepening and clitoromegaly
Androgen excess causes virilization of females, resulting in increased hirsutism, acne, menstrual abnormalities, clitoromegaly
, and in its most severe form masculinization of the external genitalia.