clinically significant bleeding


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clinically significant bleeding

Bleeding that causes hemodynamic instability (blood pressure less than 100 mm Hg or pulse more than 100 beats per min) or requires a transfusion of more than 2 units of blood in 24 hours.
See also: bleeding
References in periodicals archive ?
This review was undertaken in order to investigate current evidence behind their potential to prevent clinically significant bleeding in SRMD.
In addition to restoring coagulation function as evidenced by laboratory tests, clinically significant bleeding decreased.
Effient plus ASA, however, produced higher rates of clinically significant bleeding than clopidogrel plus ASA (see Bleeding).
Specifically, rivaroxaban 15 mg once daily in combination with single antiplatelet therapy significantly reduced the rate of clinically significant bleeding by 41 per cent (relative risk reduction; equivalent to 9.
Eltrombopag (Promacta) reduced the odds of bleeding by 76% and of clinically significant bleeding by 65%, vs.
The primary endpoint of the Rapinex 40mg Phase III trial, the occurrence of clinically significant bleeding, was the same as that seen in the IV cimetidine trial that led to its approval.
No incidence of clinically significant bleeding was noted in the preguidelines or postguidelines phase.
The primary endpoint of the study, the occurrence of clinically significant bleeding, was the same used in the cimetidine trial which led to its approval.

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