9%) patients had relapsing-remitting MS (RRMS), 74 had secondary progressive MS (SPMS), 77 had relapsing-progressive MS, 47 had primary progressive MS (PPMS), and 87 had clinically isolated syndrome
Does self-efficacy affect cognitive performance in persons with clinically isolated syndrome
and early relapsing remitting multiple sclerosis?
MRI criteria for MS in patients with clinically isolated syndromes
The Relationship between inflammation and atrophy in clinically isolated syndromes
suggestive of multiple sclerosis.
Beta interferon also has been shown in placebo-controlled trials to delay the conversion of the clinically isolated syndrome
to clinically definite disease, Dr.
Exclusion of subjects with clinically isolated syndrome
based on MRI criteria may have biased the subjects with shorter disease duration toward those with more advanced disease and potentially more RNFL involvement than a true early MS cohort.
In addition to the four major clinical subtypes of MS, patients may experience a single attack of one or more neurological symptoms; such a unifocal or multifocal episode is known as clinically isolated syndrome
(CIS) and is caused by inflammation or demyelination at one or more locations in the CNS (Gold et al.
Neurocognitive deficit can be found in 40 to 65% of patients, even in clinically isolated syndromes
in whom no cognitive deficits are detected with routine neurological examination (2,3).
The studies assessed whether the presence of MRI lesions within the brain or spinal cord could predict the risk of clinically definite multiple sclerosis in patients with a clinically isolated syndrome
Therefore, the McDonald diagnostic criteria have traditionally been applied to those individuals who present with a clinically isolated syndrome
Investigators nationwide are recruiting 640 children with early relapsing-remitting MS or clinically isolated syndrome
(a single episode of MS-like symptoms) and 1,280 children without MS for a four-year study to determine risk factors that make children susceptible to developing MS.
Different entities might lead to localized pontine lesions including multiple sclerosis (MS), variants of MS, clinically isolated syndrome
(isolated brainstem syndrome) or CNS lymphoma.