MRI criteria for MS in patients with clinically isolated syndromes
Recent studies have demonstrated that cognitive impairment is already present in patients suffering from clinically isolated syndromes
The Relationship between inflammation and atrophy in clinically isolated syndromes
suggestive of multiple sclerosis.
Beta interferon also has been shown in placebo-controlled trials to delay the conversion of the clinically isolated syndrome
to clinically definite disease, Dr.
Exclusion of subjects with clinically isolated syndrome
based on MRI criteria may have biased the subjects with shorter disease duration toward those with more advanced disease and potentially more RNFL involvement than a true early MS cohort.
In addition to the four major clinical subtypes of MS, patients may experience a single attack of one or more neurological symptoms; such a unifocal or multifocal episode is known as clinically isolated syndrome
(CIS) and is caused by inflammation or demyelination at one or more locations in the CNS (Gold et al.
Patients with a clinically isolated syndrome
and suspected MS should have, at the minimum, a brain MRI with gadolinium.
The studies assessed whether the presence of MRI lesions within the brain or spinal cord could predict the risk of clinically definite multiple sclerosis in patients with a clinically isolated syndrome
The Phase IIb placebo-controlled study [Tovaxin for Early Relapsing Multiple Sclerosis (TERMS)] was conducted in 150 patients, evaluating safety and efficacy of Tovaxin in relapsing-remitting MS patients (RRMS) and those with clinically isolated syndrome
Therefore, the McDonald diagnostic criteria have traditionally been applied to those individuals who present with a clinically isolated syndrome
We started by recruiting people with a first episode suspicious for MS, called a Clinically Isolated Syndrome
Patients with such presentations and who have not had a recent stroke or show no other identifiable cause are diagnosed with clinically isolated syndrome