clinical significance

clinical significance

A change in a patient’s/subject's clinical status that is regarded as important, whether or not it is due to an intervention in the context of a clinical trial. The phrase clinical significance should not be used unless it is operationally defined.

clinical significance

Medtalk A conclusion that an intervention has an effect of practical meaning to Pts and health care providers; even though an intervention is found to have a statistically significant effect, this effect might not be clinically significant
References in periodicals archive ?
This 280-page report presents a comprehensive analysis of the clinical significance and market needs for major blood typing, grouping, and infectious disease screening assays, including NAT tests, as well as extensive listings of companies developing or marketing new blood banking technologies and products.
Rainer Krahenmann this observation is of major clinical significance because current available drugs for the treatment of depression and anxiety disorders are not effective in all patients and are often associated with unwanted side effects.
There is a risk of focusing too heavily on statistical significance without full appreciation of the potentially broader clinical significance of results.
The trend shows no evidence for abatement and may indicate increasing epidemiologic and clinical significance," the study's authors wrote.
Cells with distinct phenotypes including stem-cell-like properties have been proposed to exist in normal human mammary epithelium and breast carcinomas, but their detailed molecular characteristics and clinical significance are unclear.
The authors conclude that in fertile men, exposure to low environmental levels of BPA may be associated with a modest reduction in markers of free testosterone, but any effects on reproductive function are likely to be small and of uncertain clinical significance.
Moreover, the panel acknowledged that the clinical significance of HER2 GH regarding the potential benefit from trastuzumab therapy is unclear.
All interactions are graded according to three guides presented at the front of the book: the interaction probability guide; the type and clinical significance guide; and the strength and character of source evidence guide.
It concludes that the clinical significance remains unclear, and that the findings do not justify a change in the acceptable daily intakes of the additives.
Each drug interaction is presented in a one-page entry, with information in interacting drugs, clinical significance, significance ratings, effects and mechanisms, management, and discussion of the studies used to document the interaction.
It has ordered a detailed study into "the clinical significance of the findings for individuals or the population in general" and prioritised the six colourings highlighted in the study within an ongoing review of food colour controls.
He acknowledges that such changes might not always have clinical significance.

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