Feline and human cells lines show identical rates of cleavage for a known furin target protein (PSCK-9), which contains an active furin cleavage site
(online Technical Appendix Figure 2).
Interestingly, this X-Pro motif is a known cleavage site
in chemokines, cytokines, and other signal peptides (65), and enzymatic removal of the two N-terminal X-Pro residues has been demonstrated in serum (66, 67) and, recently, in intracellular vesicles (68, 69).
This extensive and systematic analysis of PSA proteins and fragments demonstrated the existence of many peptide forms, including variations in glycosylation, and identified new PSA digestion products corresponding to novel cleavage sites
Discrimination of prostate cancer from benign disease by plasma measurement of intact, free prostate-specific antigen lacking an internal cleavage site
Two novel antibodies (4D4 and 5C3) bound epitopes that overlapped the most common internal cleavage site
Effect of fusion protein cleavage site
mutations on virulence of Newcastle disease virus: non-virulent cleavage site
mutations revert to virulence after one passage in chicken brain.
In this strain, 1 putative cleavage site
of the viral polyprotein responsible for processing of structural proteins was changed.
Predicted signal peptide cleavage site
marked (< >) and the predicted glycosylation site (Gennaro et al.
2A, "FR" marked on the peptide sequence is a well-known cleavage site
of chymotrypsin, a serine protease that cannot be inhibited by EDTA.
This stalk is open and accessible and contains the cleavage site
The secreted protein of 227 amino acids has a proteolytic cleavage site
University of California (Oakland, CA) has patented an isolated polynucleotide sequence encoding a chimeric CD154, comprising a first nucleotide sequence encoding an extracellular subdomain of non-human CD154, preferably murine CD154, that replaces a cleavage site
of human CD154, and a second nucleotide sequence encoding an extracellular subdomain of human CD154 that binds to a human CD154 receptor.