cleavage site


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re·stric·tion site

a site in nucleic acid in which the bordering bases are of such a type as to leave them vulnerable to the cleaving action of an endonuclease.
Synonym(s): cleavage site

re·stric·tion site

(rĕ-strik'shŭn sīt)
A site in nucleic acid in which the bordering bases are of such a type as to leave them vulnerable to the cleaving action of an endonuclease.
Synonym(s): cleavage site.

cleavage site

The location on a polypeptide molecule where peptide bonds are broken down by hydrolysis.
See also: site

cleavage

1. division into distinct parts, e.g. the double helix.
2. the early successive splitting of a fertilized ovum into smaller cells (blastomeres) by mitosis. See also holoblastic, meroblastic.

cleavage site
the places on a strand of DNA where the restriction enzyme cleaves the DNA.
References in periodicals archive ?
Feline and human cells lines show identical rates of cleavage for a known furin target protein (PSCK-9), which contains an active furin cleavage site (online Technical Appendix Figure 2).
Interestingly, this X-Pro motif is a known cleavage site in chemokines, cytokines, and other signal peptides (65), and enzymatic removal of the two N-terminal X-Pro residues has been demonstrated in serum (66, 67) and, recently, in intracellular vesicles (68, 69).
This extensive and systematic analysis of PSA proteins and fragments demonstrated the existence of many peptide forms, including variations in glycosylation, and identified new PSA digestion products corresponding to novel cleavage sites.
Discrimination of prostate cancer from benign disease by plasma measurement of intact, free prostate-specific antigen lacking an internal cleavage site at [Lys.
Effect of fusion protein cleavage site mutations on virulence of Newcastle disease virus: non-virulent cleavage site mutations revert to virulence after one passage in chicken brain.
In this strain, 1 putative cleavage site of the viral polyprotein responsible for processing of structural proteins was changed.
Predicted signal peptide cleavage site marked (< >) and the predicted glycosylation site (Gennaro et al.
2A, "FR" marked on the peptide sequence is a well-known cleavage site of chymotrypsin, a serine protease that cannot be inhibited by EDTA.
This stalk is open and accessible and contains the cleavage site.
The secreted protein of 227 amino acids has a proteolytic cleavage site between [sup.
University of California (Oakland, CA) has patented an isolated polynucleotide sequence encoding a chimeric CD154, comprising a first nucleotide sequence encoding an extracellular subdomain of non-human CD154, preferably murine CD154, that replaces a cleavage site of human CD154, and a second nucleotide sequence encoding an extracellular subdomain of human CD154 that binds to a human CD154 receptor.