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cleavage |
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cleavage /cleav·age/ (klēv´ij) 1. division into distinct parts. 2. the early successive splitting of a zygote into smaller cells (blastomeres) by mitosis.
cleavage [klē′vij] Etymology: AS, cleofan, to split 1 the series of repeated mitotic cell divisions that occur in an ovum immediately after fertilization. It transforms the single-celled zygote into a multicellular embryo capable of growth and differentiation. During cleavage, the embryo remains uniform in size as its cells, or blastomeres, become smaller with each division. Kinds of cleavage include determinate cleavage, equal cleavage, indeterminate cleavage, partial cleavage, total cleavage, and unequal cleavage. 2 the act or process of splitting, primarily a complex molecule into two or more simpler molecules. cleave, v. cleavage 1. division into distinct parts, e.g. the double helix. 2. the early successive splitting of a fertilized ovum into smaller cells (blastomeres) by mitosis. See also holoblastic, meroblastic. cleavage site the places on a strand of DNA where the restriction enzyme cleaves the DNA. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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The acquisition of a highly cleavable HA converted an avirulent strain to virulence in Pennsylvania in 1983 (H5N2), Mexico in 1994 (H5N2), Italy in 1997 (H7N1), Chile in 2002 (H7N3), and Canada in 2004 (H7N3) (Table). SGN-35 is an ADC comprised of an anti-CD30 antibody joined by an enzyme cleavable linker to a potent, synthetic drug payload, monomethyl auristatin E (MMAE), using Seattle Genetics' proprietary technology. SGN-35 is an ADC comprised of an anti-CD30 antibody linked by an enzyme cleavable peptide linker to an auristatin derivative, monomethyl auristatin E (MMAE), using Seattle Genetics' proprietary ADC technology. |
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