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cleavage
(redirected from cleavable)

   Also found in: Dictionary/thesaurus, Legal, Encyclopedia, Wikipedia, Hutchinson 0.02 sec.
cleavage /cleav·age/ (klēv´ij)
1. division into distinct parts.
2. the early successive splitting of a zygote into smaller cells (blastomeres) by mitosis.

cleav·age (klvj)
n.
1. A series of cell divisions in the ovum immediately following fertilization. Also called segmentation.
2. The splitting of a complex molecule into two or more simpler molecules. Also called scission.
3. The linear clefts in the skin, indicating the general direction of the fibers in the dermis.

cleavage
[klē′vij]
Etymology: AS, cleofan, to split
1 the series of repeated mitotic cell divisions that occur in an ovum immediately after fertilization. It transforms the single-celled zygote into a multicellular embryo capable of growth and differentiation. During cleavage, the embryo remains uniform in size as its cells, or blastomeres, become smaller with each division. Kinds of cleavage include determinate cleavage, equal cleavage, indeterminate cleavage, partial cleavage, total cleavage, and unequal cleavage.
2 the act or process of splitting, primarily a complex molecule into two or more simpler molecules. cleave, v.

cleavage
1. division into distinct parts, e.g. the double helix.
2. the early successive splitting of a fertilized ovum into smaller cells (blastomeres) by mitosis. See also holoblastic, meroblastic.

cleavage site
the places on a strand of DNA where the restriction enzyme cleaves the DNA.


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The acquisition of a highly cleavable HA converted an avirulent strain to virulence in Pennsylvania in 1983 (H5N2), Mexico in 1994 (H5N2), Italy in 1997 (H7N1), Chile in 2002 (H7N3), and Canada in 2004 (H7N3) (Table).
SGN-35 is an ADC comprised of an anti-CD30 antibody joined by an enzyme cleavable linker to a potent, synthetic drug payload, monomethyl auristatin E (MMAE), using Seattle Genetics' proprietary technology.
SGN-35 is an ADC comprised of an anti-CD30 antibody linked by an enzyme cleavable peptide linker to an auristatin derivative, monomethyl auristatin E (MMAE), using Seattle Genetics' proprietary ADC technology.
 
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