clearance /clear·ance/ (klēr´ans)
clearance
clearance,
clearance
1. the act of clearing.
2. a quantitative measure of the rate at which a substance is removed from the blood, as by the kidneys, the liver, or hemodialysis; the volume of plasma cleared per unit time. Symbol C.
3. the space between opposed structures.
blood-urea clearance urea c.
creatinine clearance the volume of plasma cleared of creatinine after parenteral administration of a specified amount of the substance.
inulin clearance an expression of the renal efficiency in eliminating inulin from the blood.
mucociliary clearance the clearance of mucus and other materials from the airways by the cilia of the epithelial cells.
urea clearance the volume of the blood cleared of urea per minute by either renal clearance or hemodialysis.
clear·ance (klîr  ns)n. The removal of a substance from the blood, expressed as the volume of blood or plasma cleared of the substance per unit time. |
clearance
[klir′əns]
Etymology: L, clarus, clear
the removal of a substance from the blood via the kidneys. Kidney function can be tested by measuring the amount of a specific substance excreted in the urine in a given length of time.
clearance,
n 1. a condition in which moving bodies may pass without hindrance.
2. removal from the blood by the kidneys (e.g., urea or insulin) or by the liver (e.g., certain dyes).
2. removal from the blood by the kidneys (e.g., urea or insulin) or by the liver (e.g., certain dyes).
clearance, interocclusal
n the difference in the height of the face when the mandible is at rest and when the teeth are in occlusion. This is determined by measuring the amount of space between the maxillary and mandibular teeth when the mandible is in the position of physiologic rest. The difference between the rest vertical dimension and the occlusal vertical dimension of the face, as measured in the incisal area. See also distance, interocclusal.
clearance, occlusal
n a condition in which the mandibular teeth may pass the maxillary teeth horizontally without contact or interference.
clearance
the act of clearing; it is a primary pharmacokinetic parameter which describes irreversible removal of a drug from the body by all processes and is made up of renal clearance and metabolic clearance.
blood-urea clearance
the volume of the blood cleared of urea per minute by renal elimination.
Bromsulphalein clearance
see sulfobromophthalein clearance test.
creatinine clearance
see creatinine.
inulin clearance
see inulin clearance.
clearance time
the time required for a drug to be eliminated after administration. Eliminated means to the point where it can no longer be detected. Of most importance in avoiding drug residues in food animals and charges of doping in sports animals.
urea clearance
blood-urea clearance.
clearance
Pharmacology The elimination of a drug, therapeutic agent, or other substance from the body or other biologic system; clearance is expressed as a hypothetical volume that is completely removed in a given unit of time; in terms of
pharmacokinetics, clearance is the product of the volume of distribution and the elimination rate constant; much of a drug's elimination is via the kidneys and clearance is commonly expressed in mL/min or L/hr. See Hepatic clearance, Renal
clearance, Therapeutic drug monitoring, Total body clearance Physiology 1. The removal of a substance from the blood by metabolism or excretion. See Nasal mucociliary clearance2. A quantitative measure of item 1
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