clear cell carcinoma


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Related to clear cell carcinoma: clear cell adenocarcinoma, Clear Cell Sarcoma, Renal cell carcinoma

carcinoma

 [kahr″sĭ-no´mah] (pl. carcinomas, carcino´mata)
a malignant new growth made up of epithelial cells tending to infiltrate surrounding tissues and to give rise to metastases. A form of cancer, carcinoma makes up the majority of the cases of malignancy of the breast, uterus, intestinal tract, skin, and tongue.
adenocystic carcinoma (adenoid cystic carcinoma) carcinoma marked by cylinders or bands of hyaline or mucinous stroma separated or surrounded by nests or cords of small epithelial cells, occurring in the mammary and salivary glands, and mucous glands of the respiratory tract. Called also cylindroma.
alveolar carcinoma bronchioloalveolar carcinoma.
basal cell carcinoma the most common form of skin cancer, consisting of an epithelial tumor of the skin originating from neoplastic differentiation of basal cells, rarely metastatic but locally invasive and aggressive. It usually occurs as small pearly nodules or plaques on the face of an older adult, particularly on a sun-exposed area of someone with fair skin. It has been divided into numerous subtypes on the basis of clinical and histological characteristics.
basosquamous carcinoma carcinoma that histologically exhibits both basal and squamous elements.
bronchioalveolar carcinoma (bronchiolar carcinoma) (bronchioloalveolar carcinoma) (bronchoalveolar carcinoma) a variant type of adenocarcinoma of the lung, with columnar to cuboidal epithelial cells lining the alveolar septa and projecting into alveolar spaces in branching papillary formations. Called also alveolar carcinoma or adenocarcinoma and bronchiolar, bronchioloalveolar, or bronchoalveolar adenocarcinoma.
bronchogenic carcinoma any of a large group of carcinomas of the lung, so called because they arise from the epithelium of the bronchial tree. Four primary subtypes are distinguished: adenocarcinoma of the lung, large cell carcinoma, small cell carcinoma, and squamous cell carcinoma.
cholangiocellular carcinoma a rare type of hepatocellular carcinoma arising from the cholangioles, consisting of two layers of cells surrounding a minute lumen. Called also bile duct carcinoma and cholangiocarcinoma.
chorionic carcinoma choriocarcinoma.
colloid carcinoma mucinous carcinoma.
cylindrical cell carcinoma carcinoma in which the cells are cylindrical or nearly so.
embryonal carcinoma a highly malignant germ cell tumor that is a primitive form of carcinoma, probably of primitive embryonal cell derivation; it usually arises in a gonad and may be found either in pure form or as part of a mixed germ cell tumor.
epidermoid carcinoma squamous cell carcinoma.
giant cell carcinoma a poorly differentiated, highly malignant, epithelial neoplasm containing many large multinucleated tumor cells, such as occurs in the lungs.
hepatocellular carcinoma primary carcinoma of the liver cells with hepatomegaly, jaundice, hemoperitoneum, and other symptoms of the presence of an abdominal mass. It is rare in North America and Western Europe but is one of the most common malignancies in parts of sub-Saharan Africa, Southeast Asia, East Asia, and elsewhere. A strong association seems to exist with chronic hepatitis B virus infection.
Hürthle cell carcinoma a malignant Hürthle cell tumor.
carcinoma in si´tu a neoplasm whose tumor cells are confined to the epithelium of origin, without invasion of the basement membrane; the likelihood of subsequent invasive growth is presumed to be high.
large cell carcinoma a type of bronchogenic carcinoma of undifferentiated (anaplastic) cells of large size, a variety of squamous cell carcinoma that has undergone further dedifferentiation.
medullary carcinoma that composed mainly of epithelial elements with little or no stroma.
mucinous carcinoma an adenocarcinoma that produces significant amounts of mucin.
nasopharyngeal carcinoma a malignant tumor arising in the epithelial lining of the nasopharynx, occurring at high frequency in people of Chinese descent. The epstein-barr virus has been implicated as a causative agent.
non–small cell carcinoma a general term comprising all lung carcinomas except small cell carcinoma, and including adenocarcinoma of the lung, large cell carcinoma, and squamous cell carcinoma.
oat cell carcinoma a form of small cell carcinoma in which the cells are round or elongated and slightly larger than lymphocytes; they have scanty cytoplasm and clump poorly.
papillary carcinoma carcinoma in which there are papillary growths that are irregular in nature arising from otherwise normal tissue; it can occur in the thyroid gland, the breast, or the bladder. Called also papillocarcinoma.
renal cell carcinoma carcinoma of the renal parenchyma, composed of tubular cells in varying arrangements; called also clear cell carcinoma.
scirrhous carcinoma carcinoma with a hard structure owing to the formation of dense connective tissue in the stroma. Called also fibrocarcinoma.
carcinoma sim´plex an undifferentiated carcinoma.
small cell carcinoma a common, highly malignant form of bronchogenic carcinoma in the wall of a major bronchus, occurring mainly in middle-aged individuals with a history of tobacco smoking; it is radiosensitive and has small oval undifferentiated cells. Metastasis to the hilum and to mediastinal lymph nodes is common.
spindle cell carcinoma squamous cell carcinoma marked by development of rapidly proliferating spindle cells.
squamous cell carcinoma
1. carcinoma developed from squamous epithelium, having cuboid cells and characterized by keratinization. Initially local and superficial, the lesion may later invade and metastasize.
2. the form occurring in the skin, usually originating in sun-damaged areas or preexisting lesions.
3. in the lung, one of the most common types of bronchogenic carcinoma, generally forming polypoid or sessile masses that obstruct the airways of the bronchi. It usually occurs in middle-aged individuals with a history of smoking. There is frequent invasion of blood and lymphatic vessels with metastasis to regional lymph nodes and other sites. Called also epidermoid carcinoma.
transitional cell carcinoma a malignant tumor arising from a transitional type of stratified epithelium, usually affecting the urinary bladder.
verrucous carcinoma
1. a variety of squamous cell carcinoma that has a predilection for the buccal mucosa but also affects other oral soft tissue and the larynx. It is slow-growing and somewhat invasive.
2. Buschke-Löwenstein tumor, so called because it is histologically similar to the oral lesion.

mes·o·ne·phro·ma

(mez'ō-ne-frō'mă),
Obsolete term for a relatively rare malignant neoplasm of the ovary and corpus uteri, thought to originate in mesonephric structures that become misplaced in ovarian tissue during embryonic development; characterized by a tubular pattern, with focal proliferation of epithelial cells with clear cytoplasm or of the hob-nail type; so-called glomeruloid structures are reported, that is, small convolutions or tufts of tiny tubate formations with capillaries extending into the spaces.
[mesonephros + -oma, tumor]

clear cell carcinoma

1 a malignant tumor of the tubular epithelium of the kidney. Characteristically the malignant cells contain abundant clear cytoplasm. See also renal cell carcinoma.
2 an uncommon ovarian neoplasm characterized by cells with clear cytoplasm.
enlarge picture
Clear cell renal cell carcinoma
Endometrium Mesonephric carcinoma A tumour of elderly women, of presumed müllerian duct origin
Prognosis Poor; 0% 5-year survival if CCC is > stage I
Liver A tumour comprising 5% of hepatocellular carcinomas (HCC) which cytologically mimics metastatic renal cell and adrenal cortical carcinomas
Prognosis Similar to ‘garden variety’ HCC
Ovary A tumour of presumed müllerian origin often associated with endometriosis, which comprises ± 10% of primary ovarian carcinomas, and affects women ± age 55
Prognosis 5-year survival, 40%

mes·o·ne·phro·ma

(mez'ō-nĕ-frō'mă)
A rare malignant neoplasm of the ovary and corpus uteri, thought to originate in mesonephric structures that become misplaced in ovarian tissue during embryonic development.
Synonym(s): clear cell carcinoma, mesometanephric carcinoma.
[mesonephros + -oma, tumor]
References in periodicals archive ?
Clear cell carcinomas of the gallbladder and extrahepatic bile ducts.
Finally, a wide range of mullerian neoplasms are know to arise in association with endometriosis, including endometrioid and clear cell carcinoma, endometrial stromal tumors, adenosarcoma, and carcinosarcoma (54,55); these diagnostic possibilities must be excluded in cases of extensive endometriosis.
EntreMed is currently conducting a Phase 2 study of ENMD-2076 in triple-negative breast cancer, a Phase 2 study of ENMD-2076 in advanced/metastatic soft tissue sarcoma, and is expecting to initiate a Phase 2 study in ovarian clear cell carcinoma.
Other than their association with endometriosis (in keeping with the type I pathway), the clinicopathologic and molecular features allowing distinction of type I from type II clear cell carcinomas are yet to be defined.
Thromboembolic complications in patients with clear cell carcinoma of the ovary.
Although the cytologic features of ChRCC are unique, several tumours, such as renal oncocytoma, clear cell carcinoma, granular cell carcinoma, hepatocellular carcinoma, adrenal cortical carcinoma, lung carcinoma, and oncocytic tumours of salivary gland and thyroid must be considered in the differential diagnosis.
Clear cell carcinoma and other rare forms of endometrial carcinoma comprise the few remaining cases.
The most common renal malignancy in adult is clear cell carcinoma followed by papillary carcinoma and chromophobe cell carcinoma (5,6).
Herbst, who in 1971 published a landmark paper in the New England Journal of Medicine about the dangers of DES, connected the dots after learning of a cluster of cases of clear cell carcinoma, a rare vaginal cancer usually seen in older women, in eight young Boston women.
Mutations in two genes, ARID1A and PPP2R1A, appear to be linked to ovarian clear cell carcinoma, one of the most aggressive forms of ovarian cancer, investigators reported.
Clear cell carcinoma is generally resistant to standard therapy.