clear cell adenocarcinoma


Also found in: Dictionary, Thesaurus, Encyclopedia, Wikipedia.

adenocarcinoma

 [ad″ĕ-no-kahr″sĭ-no´mah]
carcinoma derived from glandular tissue or in which the tumor cells form recognizable glandular structures. The World Health Organization recognizes four categories of adenocarcinoma: acinar, papillary, bronchioalveolar, and solid carcinoma with mucus formation; it can be further subclassified into well, moderate, and poorly differentiated forms.
alveolar adenocarcinoma (bronchioalveolar adenocarcinoma) (bronchiolar adenocarcinoma) (bronchioloalveolar adenocarcinoma) (bronchoalveolar adenocarcinoma) bronchioloalveolar carcinoma.
clear cell adenocarcinoma a rare malignant tumor of the female genital tract, resembling a renal cell carcinoma and containing tubules or small cysts with some cells that are hobnail-shaped and others whose cytoplasm is clear, containing abundant glycogen and inconspicuous stroma. It may occur in the ovary, uterus, cervix, or vagina. One form has been linked to in utero exposure to diethylstilbestrol. Called also clear cell carcinoma and mesonephroma.
adenocarcinoma of the lung a type of bronchogenic carcinoma made up of cuboidal or columnar cells in a discrete mass, usually at the periphery of the lungs.

clear cell ad·e·no·car·ci·no·ma

1. a histologic type of renal adenocarcinoma;
2. a histologic type of adenocarcinoma occurring chiefly in the male and female genitourinary tracts that is characterized by distinctive hobnail-cell growth of neoplastic cells in sheets, papillae, and coalescing glands.
A malignancy of the vagina and uterine cervix; 2/3 of such malignancies occur in young women exposed in utero to estrogen analogues, especially DES, as well as hexestrol or dienestrol
Risk The relative risk for DES exposed individuals is 0.014
Prognosis 5-yr survival, 80+% with local recurrence
References in periodicals archive ?
Clear cell adenocarcinoma and nephrogenic adenoma of the urethra and urinary bladder: a histopathologic and immunohistochemical comparison.
Nephrogenic adenoma can sometimes cause diagnostic difficulty in some cases, as certain histologic features, when taken out of context, may simulate the appearance of prostate adenocarcinoma, nested variant of urothelial carcinoma, and/or clear cell adenocarcinoma.
Differential Diagnosis of Nephrogenic Adenoma Nephrogenic Adenoma Differential Diagnosis Surface lesions (papillary) Urothelial papilloma PUNLMP Low-grade papillary urothelial carcinoma Involving deep lamina propria Prostatic adenocarcinoma and/or superficial muscle Urothelial carcinoma with bland histology Hobnail cells, solid growth of Clear cell adenocarcinoma of clear cells urinary bladder (rare) Abbreviation: PUNLMP, papillary urothelial neoplasm of low malignant potential.
Clear cell adenocarcinoma of the urinary bladder is rare and primarily affects women.
Clear cell adenocarcinoma tumors ranging from 1 to 7 cm in greatest dimension have been reported.
The histogenesis of clear cell adenocarcinoma of the lower urinary tract: case series and review of the literature.
Other less common variants include fetal, mucinous (colloid), signet ring cell, and clear cell adenocarcinomas, as well as rare mucinous cystadenocarcinomas.