clavulanic acid


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clav·u·lan·ic ac·id

(klav'yū-lan'ik as'id),
A β-lactam structurally related to the penicillins that inactivate β-lactamase enzymes in penicillin-resistant organisms; usually used in combination with penicillins to enhance and broaden the spectrum of the penicillins.

clavulanic acid

(klăv′yo͝o-lăn′ĭk)
n.
A compound, C8H9NO5, originally obtained from the bacterium Streptomyces clavuligerus, that inhibits action of the enzyme beta-lactamase, thus counteracting bacterial resistance to beta-lactam antibiotics. It is used in combination with antibiotics such as amoxicillin to treat infections caused by antibiotic-resistant bacteria.

clavulanic acid

A drug that interferes with beta-lactamase enzymes that inactivate many penicillin-type antibiotics, such as AMOXICILLIN. Combined with the antibiotic, this drug can overcome drug resistance.

clav·u·lan·ic ac·id

(klav'yū-lan'ik as'id)
A β-lactam structurally related to the penicillins that inactivates β-lactamase enzymes in penicillin-resistant organisms.

clavulanic acid, clavulanate

a beta-lactam product of Streptomyces spp. It binds irreversibly and inhibits β-lactamase produced by many organisms. Used commonly in combination with amoxicillin.
References in periodicals archive ?
7] Susceptibility to the following antimicrobial agents was determined immediately after pathogen identification using Etest strips (AB Biodisk, Sweden): cefixime, cefuroxime, ciprofloxacin, norfloxacin, levofloxacin, amoxicillin/ clavulanic acid and trimethoprim/sulphamethoxazole.
Cefepime, ceftazidime, imipenem, clavulanic acid, polymyxin B sulphate (PMX) and o-nitrophenyl-[beta]-D-galactoside (ONPG) were obtained from Sigma (Sigma-Aldrich UK).
Cefpodoxime, ceftazidime, cefotaxime and cefpirome and their corresponding clavulanic acid disc were used to screen for ESBL production by noting a specific difference in the zone diameters ([greater than or equal to] 5cm) which indicated a likely presence of ESBL.
The inhibitory zones of cefotaxime and ceftazidime were increased in the presence of clavulanic acid by more than 5 mm in all isolates, which confirmed ESBL production.
This can be readily demonstrated by a double disc test, but no discs of clavulanic acid are commercially available.
An Etest may also be performed using strips impregnated with ceftazidime on one end and ceftazidime with clavulanic acid on the other.
In PP patients, the clinical cure rate was 75% for 5-day telithromycin, 73% for 10-day telithromycin, and 74% for amoxicillin/clavulanic acid; the bacterial eradication rate was 87% for 5- and 10-day telithromycin and 75% for amoxicillin/ clavulanic acid.
1) We recently observed a case of acute hepatitis that occurred in a young woman and was correlated to therapy with amoxicillin/clavulanic acid, a combination of amoxicillin, a semisynthetic penicillin (eg, oxacillin), and an inhibitor of bacterial [beta]-lactamases, clavulanic acid.
Augmentin, a combination of a penicillin called amoxicillin and a chemical called clavulanic acid that prevents bacteria becoming resistant to the penicillin, has global annual sales of pounds 1.
But the drug combination that was best at preventing endometritis--a combination of intravenous ticarcillin and clavulanic acid for 48 hours followed by oral amoxicillin and clavulanic acid--may have too broad a spectrum of activity, Dr.
CHAPTER 6 The Clavulanic Acid Strain Improvement Program at DSM Anti-Infectives
Tenders are invited for Cap / Tab Containing Amoxycillin 250Mg Plus Clavulanic Acid 125 Mg 375 Mg