clavulanic acid


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clav·u·lan·ic ac·id

(klav'yū-lan'ik as'id),
A β-lactam structurally related to the penicillins that inactivate β-lactamase enzymes in penicillin-resistant organisms; usually used in combination with penicillins to enhance and broaden the spectrum of the penicillins.

clavulanic acid

(klăv′yo͝o-lăn′ĭk)
n.
A compound, C8H9NO5, originally obtained from the bacterium Streptomyces clavuligerus, that inhibits action of the enzyme beta-lactamase, thus counteracting bacterial resistance to beta-lactam antibiotics. It is used in combination with antibiotics such as amoxicillin to treat infections caused by antibiotic-resistant bacteria.

clavulanic acid

A drug that interferes with beta-lactamase enzymes that inactivate many penicillin-type antibiotics, such as AMOXICILLIN. Combined with the antibiotic, this drug can overcome drug resistance.

clav·u·lan·ic ac·id

(klav'yū-lan'ik as'id)
A β-lactam structurally related to the penicillins that inactivates β-lactamase enzymes in penicillin-resistant organisms.

clavulanic acid, clavulanate

a beta-lactam product of Streptomyces spp. It binds irreversibly and inhibits β-lactamase produced by many organisms. Used commonly in combination with amoxicillin.
References in periodicals archive ?
7 They can be differentiated from ESBLs in their hydrolysis of cephamycins along with other cephalosporins except fourth generation and no inhibition by clavulanic acid.
ESBL detection was done by using Mueller Hinton agar plate and Cefotaxime (30 [micro]g), Cefotaxime clavulanic acid (30/10 [micro]g) and Ceftazidime (30 [micro]g), Ceftazidime clavulanic acid (30/10 [micro]g) placed at 20 mm distance apart; there was increase in zone size of more than 5 mm of either antimicrobial agent tested in combination with clavulanate vs the zone diameter of the agent when tested alone.
The outpatients were discharged on oral amoxicillin and clavulanic acid (875 mg per 125 mg every 8 hours) or, in those with penicillin allergy, the combination of ciprofloxacin (500 mg every 12 hours) and metronidazole (500 mg every 8 hours).
An isolate showing enhanced zone of (Greater than or Equal to) 5mm with antibiotic combined with clavulanic acid as compared to a zone of antibiotic alone on a disc was phenotypically designated as ESBL producer.
10) The determination of inhibition by clavulanic acid is a common criteria used in all phenotypic methods for the detection of ESBL.
Moxifloxacin may have a slight advantage in terms of convenience, as it was given once daily for 5 days, compared with twice daily for 7 days for the amoxicillin - clavulanic acid, according to Dr.
The MICs of ceftazidime, test flavonoids (galangin, quercetin and baicalein) and clavulanic acid alone against six strains of S.
A screening test is then performed with clavulanic acid.
Based on our finding a test using discs containing piperacillin and piperacillin-tazobactam (PtPc) disc at a distance of 20 mm would act as a useful screening procedure for AmpC production as AmpC [beta]-lactamase producers are more susceptible to tazobactam as compared to clavulanic acid.
The median time to cessation of otorrhea was 4 days in the ciprofloxacin/dexamethasone group and 7 days in the amoxicillin / clavulanic acid group.
We conducted a randomized, double-blind, multicenter study to compare the clinical efficacy and safety of oral telithromycin, at 800 mg once daily for 5 or 10 days, with that of amoxicillin/ clavulanic acid, at 500/125 mg three times daily for 10 days, in adults with acute maxillary sinusitis (AMS).