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clavulanic acid

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clav·u·lan·ic acid (klvy-lnk)
n.
A drug that inhibits the action of beta-lactamase produced by bacteria, thereby counteracting bacterial resistance to beta-lactam antibiotics.
clavulanic acid, clavulanate
a beta-lactam product of Streptomyces spp. It binds irreversibly and inhibits β-lactamase produced by many organisms. Used commonly in combination with amoxicillin.
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We observed synergy between clavulanic acid, oxyiminocephalosporins, and aztreonam for 34 strains (36.
CTX-M [beta]-lactamases in Escherichia coli from Community-acquired ... by Ruppe, Etienne; Hem, Sopheak; Lath, Sovannarith; Gautier, Valerie; Ariey, Frederic; Sarthou, Jean-Lo / Emerging Infectious Diseases
However, Amoxicillin can be broken down by beta-lactamase producing bacteria and can be given with clavulanic acid.
Know the Facts About Amoxicillin by Heather Colman / Health care industry community
In all strains with ES[beta]Ls, the MICs for one or more of the extended-spectrum cephalosporins or aztreonam should decrease in the presence of clavulanic acid as determined in phenotypic confirmatory testing.
Bacterial resistance: how to detect three types by Shima, Susan M.; Donahoe, Lawrence W. / Medical Laboratory Observer
 
 
 
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