CLDN9

(redirected from claudin-9)

CLDN9

A gene on chromosome 16p13.3 that encodes claudin-9, an integral membrane protein of the claudin family, the members of which form a physical barrier that prevents solutes and water from passing freely into the interstitial space between epithelial or endothelial cell sheets, and play critical roles in maintaining cell polarity and signal transduction.

Molecular pathology
Claudin-9 is a co-factor for entry of hepatitis C virus; CLDN9 is required for sensory cells in auditory canal; deficiency is associated with deafness.
References in periodicals archive ?
The researchers behind the present study have revealed that they used a deaf mouse model, generated at The Jackson Laboratory, to identify the deafness-causing defect in the claudin-9 gene.
They showed that the mutated gene fails to produce normal claudin-9 protein, which is needed to maintain the proper distribution of potassium in the inner ear.
We found that claudin-9 is very important in keeping the amount of potassium on the two sides separate.
The researchers have found that when claudin-9 is mutated, potassium floods the wrong part of the sensory cells, killing most and leaving the remaining ones functionally defective.