CLDN5

(redirected from claudin-5)

CLDN5

A gene on chromosome 22q11.21 that encodes claudin-5, an integral membrane protein of the claudin family, the members of which form a physical physical barrier that prevents solutes and water from passing freely into the interstitial space between epithelial or endothelial cell sheets, and play critical roles in maintaining cell polarity and signal transduction.

Molecular pathology
CLDN5 mutations are linked to velocardiofacial syndrome.
References in periodicals archive ?
Endothelial cells of the hemangioma component were positive for claudin-5 endothelium-specific immunohistochemical marker, and the leiomyoma component was positive for a-smooth muscle actin.
We investigated the effects of GTPs on the expression of claudin-5, occludin, and ZO-1, and the corresponding cellular mechanisms involved in the early stage of cerebral ischemia.
At different time points, the expression of claudin-5, occludin, ZO-1, and PKCa signaling pathway in microvessel fragments of cerebral ischemic tissue were evaluated.
The decreased mRNA and protein expression levels of claudin-5, occludin, and ZO-1 in microvessel fragments of cerebral ischemic tissue were significantly prevented by treatment with GTPs at the same time points after ischemia in rats.
RESULTS: Oral administration of coplanar PCB126, mono-ortho-substituted PCB118, and non-coplanar PCB153 (each at 150 [micro]mol/kg body weight) differentially altered expression of the TJ proteins claudin-5, occludin, and zonula occludens-1 in brain capillaries.
The transmembrane proteins occludin and claudin-5 form the primary seal of the TJs.
Primary antibodies for occludin, ZO-1, and claudin-5 were obtained from Invitrogen (Camarillo, CA), and all secondary antibodies were purchased from Santa Cruz Bio technology (Santa Cruz, CA).
2008), our studies focused on the effects of PCBs on protein expression of claudin-5, occludin, and ZO-1.
Forty-eight hours after administration of PCB118 or PCB153, we observed a significant decrease in the expression of claudin-5 compared with the vehicle control group.
A semiqualitative analysis by immunofluorescence microscopy indicated that treatment with PCBs decreased the intensity and disrupted the continuity of claudin-5 immunoreactivity, similar to results of Western blotting.
The team are already working on a way to block claudin-5 production in the eye only.
Overexpression of claudin-5 but not claudin-3 induces formation of trans-interaction-dependent multilamellar bodies