CLDN4

(redirected from claudin-4)

CLDN4

A gene on chromosome 7q11.23 that encodes claudin-4, an integral membrane protein of the claudin family, the members of which form part of the tight junction strands and may play a role in embryonic and post-natal organogenesis and function.

Molecular pathology
CLDN4 is deleted in Williams-Beuren syndrome, a multisystem neurodevelopmental disorder.
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References in periodicals archive ?
Endometrial claudin-4 and leukemia inhibitory factor are associated with assisted reproduction outcome.
Increased amounts of the cell cycle proteins cyclin E and p16, amplification and overexpression of the ERBB2 [v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2] gene (which encodes the ERBB2 receptor tyrosine kinase), loss of BAF250A production, and altered amounts of the cell adhesion proteins claudin-3, claudin-4, L1CAM (L1 cell adhesion molecule), EpCAM (epithelial cell adhesion molecule), and E-cadherin have also been documented [reviewed in (24)].
E-cadherin and claudin-4 expression has circadian rhythm in adult rat kidney.
42 protein 415 CLDN4 Claudin-4 Hypomethylation 7q11.
This action results in decreased expression of the tight junction protein claudin-4, which in turn reduces the barrier function of the intestine (Pinton et al.
Tight junction proteins claudin-3 and claudin-4 are frequently overexpressed in ovarian cancer but not in ovarian cystadenomas.