CLDN12

(redirected from claudin-12)

CLDN12

A gene on chromosome 7q21 that encodes claudin-12, an integral membrane protein of the claudin family, the members of which form a physical barrier that prevents solutes and water from passing freely into the interstitial space between epithelial or endothelial cell sheets, and play critical roles in maintaining cell polarity and signal transduction. Claudin-12 is expressed in the inner ear and bladder epithelium. 

Molecular pathology
CLDN12 is overexpressed in colorectal carcinoma.
References in periodicals archive ?
This set of experiments focuses on the amplification of two PCR products: one for claudin-2 and one for claudin-12.
calculate and estimate optimal annealing temperature for primers of claudin-2 and claudin-12 DNA sequences,
Table 1 shows the primers used in this exercise to amplify intestinal cDNA for claudin-2 and claudin-12.
In the second module, cDNA is used in PCR to amplify cDNA for claudin-2 and claudin-12 at varying annealing temperatures.
Primer sequences for claudin-2 and claudin-12 are shown in Table 1, with details concerning composition and annealing temperatures.
The claudin-12 primers were able to produce the expected PCR product over a wider range of annealing temperatures than the claudin-2 primers because the claudin-12 primers have a higher [T.