CLDN1

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CLDN1

A gene on chromosome 3q28-q29 that encodes claudin-1, an integral membrane protein of the claudin family, the members of which form part of tight junction strands, providing a continuous seal around cells and serving as a physical barrier to prevent solutes and water from passing freely into the interstitial space.

Molecular pathology
CLDN1 loss of function mutations cause neonatal ichthyosis-sclerosing cholangitis syndrome.
References in periodicals archive ?
Fucoidan enhances intestinal barrier function by upregulating the expression of claudin-1.
The HCV particles interact with a number of putative HCV receptors, including CD81, SR-BI (scavenger receptor class B type I), and Claudin-1 (63, 64).
A claudin-1 deficiency has been associated with NISCH syndrome (neonatal ichthyosis-sclerosing cholangitis, a familial form of ichthyosis) (Morita et al.
Indigo naturalis also up-regulated claudin-1 expression and restored tight junction proteins in keratinocytes, helping to restore the impaired epidermal barrier (Lin et al.
GLP-2 could recover and maintain the integrity of the intestinal mucosa epithelium barrier by increasing the expressions of zonula occludens-1 (ZO-1), claudin-1 and occludin in obstructive jaundice rats (Chen et al.
Anna De Benedetto and co-authors showed that a protective protein called claudin-1 is significantly weakened in the skin of eczema patients but not in those with normal skin or other skin conditions.
These tumors express perineural markers, including epithelial membrane antigen (EMA), GLUT-1, claudin-1, and vimentin (Figure 2, D), and do not express keratins; muscle markers, including actin and desmin; CD34; or neural markers, including S100.
In ex-vivo testing, Osmoline increased the presence of several water-regulating molecules, including hyaluronic acid, aquaporin-3, claudin-1 and filaggrin.
CD81 along with human scavenger receptor SR-BI, and tight junction molecules claudin-1 (CLDN) and occludin (OCLN) are the most important receptors that mediate HCV entry (46).
Aliquots of the mature tissue aggregates were fixed with paraformaldehyde (4% paraformaldehyde in 1x phosphate-buffered saline [PBS]) for 30 min at room temperature and then stained with antibodies specific for tight junction markers ZO-1, Occludin, Claudin-1, and E-cadherin (Zymed Laboratories [Invitrogen], South San Francisco, CA, USA).
Other antibodies/antigens that may become more popular in the future include NKI-C3, (15) p16, (16) galectin-3, (17) COX-2, (18) TRP, (19) survivin, (20) and claudin-1.
On further investigation, they found that a particular tight junction protein, claudin-1, which determines the strength and permeability of tight junctions in skin, is significantly reduced in the skin of eczema patients, but not in healthy individuals or individuals with psoriasis, another common chronic skin disease.