CLDN7

(redirected from claudin 7)

CLDN7

A gene on chromosome 17p13.1 that encodes claudin-7, an integral membrane protein of the claudin family, the members of which form a physical barrier that prevents solutes and water from passing freely into the interstitial space between epithelial or endothelial cell sheets, and play critical roles in maintaining cell polarity and signal transduction.

Molecular pathology
Differential expression of CLDN7 has been described in malignancies of the breast, ovary, liver, urinary tract, prostate, lung, head, neck, thyroid and elsewhere.
References in periodicals archive ?
This group of markers (parvalbumin, claudin 7 and 8, and CD117) has been shown to be positive in a high percentage of chromophobe RCCs and oncocytomas but is typically negative in other types of RCC.
Limited studies on their expression in renal neoplasm showed that most chromophobe RCC and oncocytoma expressed both claudin 7 and 8, but they are seen in no or very few other RCCs.