CLDN25

CLDN25

A gene on chromosome 11q23.2 that encodes claudin-25, an integral membrane protein of the claudin family, the members of which provide a physical barrier preventing solutes and water from passing freely into the interstitial space between epithelial or endothelial cell sheets; they play critical roles in maintaining cell polarity and signal transduction, as well as tight junction-specific obliteration of the intercellular space by means of a calcium-independent mechanism.