CLDN2

(redirected from claudin 2, SP82, OTTHUMP00000023793, claudin-2)

CLDN2

A gene on chromosome Xq22.3-q23 that encodes claudin-2, an integral membrane protein of the claudin family, which form part of tight junction strands, providing a continuous seal around cells and serving as a physical barrier to prevent solutes and water from passing freely into the interstitial space. Claudins play critical roles in maintaining cell polarity and signal transduction. Claudin-2 is expressed in the intestine.