CLDN14

(redirected from claudin 14)

CLDN14

A gene on chromosome 21q22.3 that encodes claudin-14, an integral membrane protein of the claudin family, the members of which form a physical barrier that prevents solutes and water from passing freely into the interstitial space between epithelial or endothelial cell sheets, and play critical roles in maintaining cell polarity and signal transduction. Claudin-14 is an integral membrane protein and a component of tight junction strands, which binds specifically to the WW domain of Yes-associated protein.

Molecular pathology
CLDN14 mutations cause an autosomal recessive form of nonsyndromic sensorineural deafness.
References in periodicals archive ?
But when people eat a diet high in calcium or salt and don't drink enough water, the small RNA molecules release their hold on claudin 14.
He is optimistic, however, that drugs could be developed to target the short stretches of RNA that are intimately linked to claudin 14.
The SNP is in the gene encoding claudin 14 (CLDN14), a protein expressed in the kidney and one of a family of membrane proteins that regulate the passage of ions and small solutes between cells.