CLDN1

(redirected from claudin 1)

CLDN1

A gene on chromosome 3q28-q29 that encodes claudin-1, an integral membrane protein of the claudin family, the members of which form part of tight junction strands, providing a continuous seal around cells and serving as a physical barrier to prevent solutes and water from passing freely into the interstitial space.

Molecular pathology
CLDN1 loss of function mutations cause neonatal ichthyosis-sclerosing cholangitis syndrome.
References in periodicals archive ?
However, further investigation led to the identification of claudin 1 & 2, integral membrane proteins that can form strand structures without occludin.