clathrin


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clath·rin

(klath'rin),
The principal constituent of a polyhedral protein lattice that coats eukaryotic cell membranes (vesicles) and coated pits and appears to be involved in protein secretion and membrane trafficking. This protein also occurs in synaptic vesicles.
[L. clathri, lattice]

clathrin

a protein of eukaryotic cells occurring in indentations of the plasma membrane. These indentations are known as clathrin-coated pits; see RECEPTOR-MEDIATED ENDOCYTOSIS.

clathrin

a highly conserved, fibrous protein, mol. wt 180,000, which forms a characteristic polyhedral coat on the surface of coated pits and coated vesicles.
References in periodicals archive ?
Some recently identified genes that also contribute to AD risk include CLU and PICALM (phosphatidylinositolbinding clathrin assembly protein), among others.
Without clathrin, cells divide erratically and unevenly a phenomenon that is one of the hallmarks of the disease.
Y828C sequence variation did not colocalize with a clathrin marker in CHO cells, as opposed to the wild-type, in an experiment using fluorescent probes detected by a confocal laser microscopy (Fig.
Internalization and desensitization of the oxytocin receptor is inhibited by dynamin and clathrin mutants in human embryonic kidney 293 cells.
28) Clathrin is the major protein constituent of the coat that surrounds organelles to mediate selective protein transport.
Schein came to the cagelike molecules because he was curious about clathrin, a protein that assembles itself in cages.
Clathrin is involved in moving resources inside and outside cells, and in that process it forms only a handful number of shapes.
Fusion of the ALK gene to the clathrin heavy chain gene, CLTC, in inflammatory myofibroblastic tumor.
Through clathrin, polysaccharides can be absorbed intact into the blood and lymphatic systems, then delivered to the whole body.
Clathrin coat is needed for invagination of the cell membrane.
The team determined that this protein is a specialized form of an omnipresent housekeeping protein called clathrin, which is known to be instrumental in moving proteins between cellular compartments.
Deletion of a putative clathrin binding domain in the C terminal half by site specific mutagenesis abolished TOR's ability to internalize the adenosine transporter.

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