clastogen


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clas·to·gen

(klas'tō-jen),
An agent (for example, certain chemicals, x-rays, ultraviolet light) that causes breaks in chromosomes.
[G. klastos, broken, + genos, birth]

clas·to·gen

(klas'tō-jen)
An agent (e.g., certain chemicals, x-rays, ultraviolet light) that causes breaks in chromosomes.
[G. klastos, broken, + genos, birth]

clastogen

(klăs′tă-jĕn″) [Gr. klastos, broken + gennan, to produce]
Any agent that can damage a chromosome. Examples of clastogens include chemotherapeutic agents (e.g., cyclophosphamide or nitrogen mustard), and many forms of electromagnetic radiation (e.g., ultraviolet light or x-rays).

clastogen

an agent causing fragmentation of the CHROMOSOME.
References in periodicals archive ?
According to clastogen and the species studied, the frequency of micronuclei may suffer important variations.
Kikuchi, A Comparison of Diameters of Micronuclei Induced by Clastogens and by Spindle Poisons.
2] and WTHBF-6 (hTERT+) cells 24 h Sodium chromate WTHBF-6 cells are as a useful 1-10 [micro]M lung cell model 24 h Lead chromate Cr(VI) is the proximate clastogen 52 0.
Benzene is a well-known clastogen that requires metabolic activation to be mutagenic.
Micronucleus assay in lymphocytes as a tool to biomonitor human exposure to aneuploidogens and clastogens.
Relative protection given by extract of Phyllanthus emblica fruit and an equivalent amount of vitamin C against a known clastogen - cesium chloride.
Such experiments with a number of crude vegetable and fruit extracts have demonstrated the anticlastogenic activities of these extracts against known clastogens (Table III).
and equivalent amounts of synthetic ascorbic acid (vitamin C) against a number of known clastogens, including zinc chloride, metanil yellow, and ethyl parathion (Giri & Banerjee, 1986), nickel and lead (Agarwal et al.
The mechanisms by which crude vegetable and fruit extracts reduce the cytotoxic effects of various clastogens may be different for different plants.
They are the sum of interactions between the components and the clastogens or mutagens added (Sharma, 1990).