classical pathway


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Related to classical pathway: alternative pathway, Complement system

classical pathway

n. Immunology
The primary pathway in the innate immune system, consisting of the activation of complement by an antigen-antibody complex.

classical, classic

the first recognized form of the item; serving as a standard model or guide. See also classical conditioning, east coast fever.

classical conditioning
classical pathway
one of the two pathways of complement activation, initiated by antigen-antibody complexes and involving C1, C2 and C4. It leads to activation of C3 and the terminal pathway. See also alternate complement pathway.
classical swine fever
now the universally accepted name for hog cholera and different from African swine fever (ASF). A highly infectious disease of pigs caused by a pestivirus and characterized in its classical form by high fever, lassitude, purple discoloration of abdominal skin, conjunctivitis and nervous signs including circling, incoordination, tremor and convulsions. Most affected pigs die at 5 to 7 days with a characteristic petechiation under the kidney capsule—turkey egg kidney. There is a second form, characterized by nervous signs and caused by a strain of virus of lower virulence. Other syndromes caused by low virulence strains are reproductive inefficiency and congenital defects including myotonia congenita. Also known as congenital trembles.
References in periodicals archive ?
Because CIMP-L CRCs can arise from both the classical pathway and the serrated neoplasia pathway, it is necessary to develop molecular or immunohistochemical markers to identify CIMP-L serrated pathway adenocarcinomas.
For example, lipopolysaccharide of Mycoplasma species interacting with C1 and inducing an antibody-independent activation of the complement system via the classical pathway (Bredt et al.
These make boosting hemolytic complement activity in the classical pathway significantly higher than in the alternative pathway.
It is not C1s of the classical pathway because C1 is effectively inactivated by the removal of calcium ions (40) and any C1s activated would be under the rigorous control of C1 inhibitor (41).
in EDTA/Futhan plasma) were much higher than in normal EDTA/Futhan plasma, which is consistent with classical pathway activation (Fig.
Many of the events monitored in these liver transplant patients appeared to involve primarily the classical pathway (i.
2] actions not only through the classical pathway but also via other alternative pathways that do not necessarily involve classical ERs (Nadal et al.
The system can be activated in the classical pathway by an immune reaction or in the alternative pathway by some polysaccharides, lipopolysaccharides, immune-complexes or aggregated immunoglobulins of classes (e.
If scientists can show that salicylic acid does not simply stimulate a cyanid-resistant pathway but also serves as a molecular "switch" regulating classical pathways, it may prove useful as an herbicidal ingredient, perhaps by switching off a plant's normal respiratory pathway.