class switch


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class switch

(klas switch),
Before activation, a B cell may only produce antigen-specific IgM but after appropriate immunomodulatory signals, the B cell may class switch and produce other antibody isotypes, such as IgA and IgG. All antibodies produced from the same clone will have the same antigen specificity, even though the immunoglobulin isotypes may be different.
References in periodicals archive ?
The research team led by Tasuku Honjo, a professor of molecular biology, found that a phenomenon called class switch recombination -- a genetic conversion allowing the production of antibodies by an immune cell -- can be induced in other types of cells if a special gene called AID is activated.
According to the team, class switch recombination is a phenomenon in which B lymph cell, a type of immune cell, converts a portion of its genes to produce a different type of antibodies in response to external stimulus.
For example, in a process known as class switch recombination, immune cells called B cells rearrange their DNA.
SAFARI C3 is the only totally integrated carrier class switch that incorporates -- at no additional cost -- all of the components that make up the PacketCable(TM) voice switching infrastructure, eliminating the need for operators to purchase, maintain, upgrade and regression test separate Call Management Servers, Media Gateways, Record Keeping Servers, Announcement Servers, Signaling Gateways, Ethernet Switches and CALEA servers.