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citreoviridin

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citreoviridin
the metabolite of Penicillium citreoviride thought to be the cause of yellow rice poisoning, manifested in humans and experimental animals by respiratory and circulatory failure, paralysis, convulsions and death. Identical to beriberi, originally considered to be a thiamin nutritional deficiency.


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The 2,5-dihydrofuran 15 is a precursor of the THF natural product (+)-citreoviral (16), as well as, the mycotoxins citreoviridin and verrucosidin, using the dihydrofuran double bond for oxidative functionalization.
 
 
 
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