citrate synthase

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Related to citrate synthase: Succinate dehydrogenase, ATP citrate synthase

cit·rate syn·thase

citrate (si)-synthase; an enzyme catalyzing the condensation of oxaloacetate, water, and acetyl-CoA, forming citrate and coenzyme A; an important step in the tricarboxylic acid cycle.


any salt of citric acid. Citrate is the first intermediate of the citric acid cycle and tricarboxylic acid (TCA) cycle. It also plays an important role in fatty acid synthesis which takes place in the cytoplasm. It acts as a carrier of acetyl-CoA, the construction material for fatty acids. The movement is assisted by two enzymes, citrate-condensing enzyme, which catalyzes the condensation of the acetyl unit with oxaloacetate in the mitochondria, and citrate-cleavage enzyme (citrate lyase), which catalyzes the release of the acetyl radical in the cytoplasm of the cell.

citrate cleavage enzyme
important enzyme in fatty acid synthesis from glucose; catalyzes the split of citrate to acetyl CoA and oxaloacetate.
citrate synthase
first enzyme of the TCA cycle catalyzing the formation of citrate from acetyl CoA and oxaloacetate.
References in periodicals archive ?
DNA sequences from the 21 PCR citrate synthase A gene amplicons (GenBank accession nos.
Dasgupta said this further underscores the importance of Lbk1 and the production of citrate synthase.
For the assessment of metabolic capacities and their effects on the reproductive cycle, we measured the glycolytic enzymes phosphoglucose isomerase (PGI), phosphomannose isomerase (PMI), pyruvate kinase (PK), one enzyme of protein metabolism (aspartate aminotransferase [AAT]), and the mitochondrial enzyme citrate synthase (CS) in the adductor muscle of scallops P.
Citrate synthase and pyruvate kinase activities during early life stages of the shrimp Farfantepenaeus paulensis Crustacea, Decapoda, Penaeidae: effects of development and temperature.
Citrate synthase activity measured in the muscle and the digestive gland of scallops (Placopecten magellanicus) collected during 2003 near Magdalen Islands (Quebec, Canada).
Pearson's product correlations were used to determine the relationship between the distance run and the citrate synthase activity and between the distance run and the percentage of satellite cells.
Citrate synthase activity The citrate synthase activity in both groups is shown in Table 2.
As expected, the voluntary running model enhanced citrate synthase activity but caused no changes in absolute muscle mass or fiber size.
In our study, the absolute muscle weight and mean muscle fiber area determined using a simple method did not differ significantly between the control and training groups, although the citrate synthase activity was increased in the training group.
In addition, citrate synthase activity was significantly higher in the training group, and the increase was also a function of the distance run (r = 0.
Voluntary running training causes an increase of citrate synthase activity in the rat plantaris muscle but does not affect muscle weight and mean fiber area in the rat plantaris muscle.
The capacity of classic markers for mitochondrial density, ie, the capacity of citrate synthase (CS) and succinate dehydrogenase (SDH), as well the capacity of cytochrome c oxidase (COX) and beta-hydroxyacyl-CoA dehydrogenase (HAD), was determined in homogenized muscle biopsy samples obtained from the vastus lateralis muscle of nonexercising healthy young (age 20 [+ or -] 2 yr) subjects (31 women, 7 men).