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citalopram hydrobromide |
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Citalopram hydrobromide Celexa; a SSRI that is highly specific for serotonin reuptake. Mentioned in: Antidepressant Drugs, SSRI
citalopram hydrobromide Celexa Pharmacologic class: Selective serotonin reuptake inhibitor Therapeutic class: Antidepressant Pregnancy risk category C FDA Boxed Warning• Drug may increase risk of suicidal thinking and behavior in children and adolescents with major depressive disorder and other psychiatric disorders, especially during first few months of therapy. Risk must be balanced with clinical need, as depression itself increases suicide risk. With patient of any age, observe closely for clinical worsening, suicidality, and unusual behavior changes when therapy begins. Advise family to observe patient closely and communicate with prescriber as needed. ActionUnclear. Thought to potentiate serotonergic activity in CNS by inhibiting neuronal uptake of serotonin. AvailabilityOral solution: 10 mg/5 ml Orally disintegrating tablets (ODT): 10 mg, 20 mg, 30 mg, 40 mg Tablets: 10 mg, 20 mg, 40 mg ⊘Indications and dosages ➣ Depression Adults: Initially, 20 mg P.O. daily; may increase by 20 mg/day at weekly intervals, up to 60 mg/day. Usual dosage is 40 mg/day. For ODT, start with 20 mg tablet dissolved on the tongue daily; may increase to 40 mg daily; may further increase to 60 mg daily. Dosage adjustment• Hepatic impairment Off-label uses• Alcoholism Contraindications• Hypersensitivity to drug PrecautionsUse cautiously in: Administration☞ Don't give within 14 days of MAO inhibitor; life-threatening interactions may occur.
Adverse reactionsCNS: apathy, confusion, drowsiness, insomnia, migraine, weakness, agitation, amnesia, anxiety, dizziness, fatigue, poor concentration, tremor, paresthesia, deepening of depression, suicide attempt CV: orthostatic hypotension, tachycardia EENT: abnormal visual accommodation GI: nausea, vomiting, diarrhea, abdominal pain, dyspepsia, flatulence, ncreased saliva, dry mouth, increased appetite, anorexia GU: polyuria, amenorrhea, dysmenorrhea, ejaculatory delay, erectile dysfunction, decreased libido Musculoskeletal: joint pain, myalgia Respiratory: cough Skin: rash, pruritus, diaphoresis, photosensitivity Other: altered taste, fever, yawning, weight changes InteractionsDrug-drug. Carbamazepine: decreased citalopram blood level Centrally acting drugs (such as antihistamines, opioids, sedative-hypnotics): additive CNS effects Erythromycin, itraconazole, ketoconazole, omeprazole: increased citalopram blood level 5-hydroxytryptamine1 receptor agonists (such as sumatriptan, zolmitriptan): increased risk of adverse reactions Lithium: potentiation of serotonergic effects MAO inhibitors: life-threatening reactions Tricyclic antidepressants (TCAs): altered TCA pharmacokinetics Drug-herbs. St. John's wort, S-adenosylmethionine (SAM-e): increased risk of serotonergic reactions, including serotonin syndrome Drug-behaviors. Alcohol use: additive CNS depression Sun exposure: photosensitivity Patient monitoring• If patient is receiving lithium concurrently, watch closely for potentiation of serotonergic effects. Patient teaching• Instruct patient to take drug with full glass of water at same time every day. Want to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit the webmaster's page for free fun content. |
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CITALOPRAM HYDROBROMIDE (Celexa) is a selective serotonin reuptake inhibitor (SSRI) with established safety and efficacy in the treatment of depression. In the first phase, 579 subjects with MDD received first-line treatment with citalopram hydrobromide for eight weeks, 20mg daily for the first four weeks and 40mg daily for the next four weeks. In the first phase, 579 subjects with MDD received first-line treatment with citalopram hydrobromide for eight weeks, 20mg daily for the first four weeks and 40mg daily for the next four weeks. |
citalopram hydrobromide |
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