cis-platinum


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cisplatin

A chemotherapeutic that forms covalent bonds and crosslinks with DNA, which is used for head and neck, ovarian, testicular, and bladder cancers and lymphomas.

Adverse effects
Nephrotoxicity, nausea, sensory neuropathy.

Management for adverse effects
• Nephrotoxicity: adequate hydration to maintain renal flow and high chloride concentration.
• Nausea: ondansetron, a selective antagonist of serotonin S3 receptors.
• Neuropathy: amifostine, growth factors, glutathione, Org 2766, acetyl-L-carnitine, vitamin E have all been tried; per Cochrane review, none proved effective; more studies are needed.

cisplatin

, cis-platinum (sĭs′plă-tĭn)
A drug used to treat cancers, esp. solid tumors such as testicular and ovarian carcinoma. Common side effects of this drug include severe nausea and vomiting and renal failure.

cisplatin, cis-platinum

a platinum-containing complex used as an antineoplastic agent whose main mode of action resembles that of alkylating agents—production of cross-links between the two strands of DNA in the double helix so that DNA cannot be replicated and the cells cannot divide.
References in periodicals archive ?
Alcohol Adriamycin Amiodarone Chloramphenicol Cis-platinum Dapsone Diphenylhydantoin Disulfiram (Antabuse) (Dilantin) Glutethimide (Doriden) Gold Hydralazine (Apresoline) Isoniazid (INH) Mega Dose of Vitamin A Mega Dose of Vitamin D Metronidazole (Flagyl) Nitrofurantoin Nitrous Oxide (Furadantin,Macrodantin) (chronic repeated inhalation) Perhexiline (Pexid) Penicillin (Large IV doses only) Pyridoxine (Vitamin B6) Vincristine
42] According to Pfeiffer et al, cis-platinum appears to be the most effective agent, as patients who received it had a median survival of 16 months, compared with only 8 months for patients who were treated with other regimens.
Carter brings to the Telik drug development team extensive successful pharmaceutical industry experience in the development and approval of novel cancer drugs, including taxol and cis-platinum, which are currently two of the most important drugs for cancer treatment," said Michael M.
Importantly, cross-resistance to the clinically important drugs adriamycin, cis-platinum, and taxol did not occur in cell lines that were resistant to TLK286.