A preliminary evaluation of a recombinant circumsporozoite protein
vaccine against Plasmodium falciparum malaria.
The malaria circumsporozoite protein
has two functional domains, each with distinct roles as sporozoites journey from mosquito to mammalian host.
Using a proprietary screening technology, GenVec identified new antigens that are as protective as the gold standard: circumsporozoite protein
, or CSP, in an industry-accepted mouse model of malaria.
Genetic polymorphism in T-cell epitopes of the circumsporozoite protein
of Plasmodium falciparum clones and isolates from India.
vivax polymorphs VK 210 and VK 247 circumsporozoite protein
(CSP) positivity rates in anopheline pools (5 females per species) trapped indoors and outdoors from 2004 through 2005 were detected by using the VecTest Malaria Panel Assay dipstick ELISA (Medical Analysis Systems, Inc.
The CRADA, titled, Clinical Trial on Safety, Immunogenicity, and Efficacy of a Prime Boost Regimen of DNA- and Adenovirus-vectored Malaria Vaccines Encoding Plasmodium Falciparum Circumsporozoite Protein
and Apical Membrane Antigen 1 in Malaria-Naove Adults in the United States, is a two-year study that will utilize the Biojector[R] 2000 in human subjects.
today announced that it has awarded Althea Technologies a contract for the current Good Manufacturing Practice (cGMP) manufacturing of circumsporozoite protein
(CSP) from Plasmodium falciparum, an important and proven component of an effective malaria vaccine.
Identification of a sub-population of immune Nigerian volunteers by antibodies to the circumsporozoite protein
of Plasmodium falciparum.
Two types of repetitive epitope have been described in the circumsporozoite protein
gene of P.
Three of the antigens, circumsporozoite protein
(CSP), liver stage antigen-1 (LSA1), and antigen 2 (Ag2) are expressed from a single adenovector and target the liver stage of the disease while two additional antigens, merozoite surface protein-1 (MSP1) and apical membrane antigen-1 (AMA1), are expressed from a second adenovector and target the blood stage of the disease; all are thought to be important in preventing or limiting the severity of malaria.
Awards Althea Technologies a Contract for cGMP Manufacturing of Circumsporozoite Protein
from Plasmodium falciparum, a Key Malaria Antigen, issued 24-Oct-2012 by Pfenex Inc.
This led to an immediate hunt for protective antigens of the sporozoite, and the circumsporozoite protein
(CSP) was identified (16).