cingulin

cingulin

A rod-shaped homodimeric (108 kD subunits) protein on the cytoplasmic domain of vertebrae tight junctions encoded by CGN on chromosome 1q21. Cingulin is a marker of epithelial differentiation and plays a role in cell proliferation, and in inhibiting Rho signaling.
References in periodicals archive ?
TJ proteins identified include transmembrane proteins; occludin and claudin, and cytoplasmic plaque proteins; ZO-1, ZO-2, ZO-3, cingulin, and 7H6.
They bind to the intracellular proteins zonula occludens (ZO)-l, ZO-2, cingulin, and/or 7H6 that couple the TJs to the actin cytoskeleton of endothelial cells (Abbott et al.