cilastatin


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cilastatin

 [si″lah-stat´in]
an enzyme inhibitor used with imipenem to decrease the metabolism of imipenem in the kidneys and increase its concentration in the urine; administered as the sodium salt.

cilastatin

/ci·la·stat·in/ a dipeptidase inhibitor used with imipenem to decrease the metabolism of imipenem in the kidneys and increase its concentration in the urine; administered as the sodium salt.

cilastatin

A drug used in combination with the beta-lactam antibiotic imipenem (carbapenem) to prevent its degradation in the kidneys so that its action can be prolonged. A brand name for the combination is Primaxin IV.

cilastatin

an inhibitor of dehydropeptidase I, an enzyme found in renal tubules. Used in association with the antibiotic, imipenem, to prevent its inactivation.
References in periodicals archive ?
Patients in the tigecycline group also experienced higher rates of infection and leukocytosis than patients in the imipenem/ cilastatin group (P < 0.
Imipenem/ cilastatin (25 mg 4x/d) and amikacin (15 mg 2x/d) were given for 2 days.
Additional Patient Assistance Programs -- There are separate patient assistance programs for a number of other prescription medicines, including CANCIDAS(R) (caspofungin acetate) for Injection, CRIXIVAN(R) (indinavir sulfate) Capsules, EMEND(R) (aprepitant), INVANZ(R) (ertapenem for injection), PRIMAXIN(R) (imipenem and cilastatin for injectable suspension) and PRIMAXIN(R) (imipenem and cilastatin for injection).
Tenders are invited for Imipenem 500Mg With Cilastatin 500Mg Inj In Vial - With Diluent
Tenders are invited for Inj Imipenem 500Mg And Cilastatin 500Mg Vial
Invitation to tender: drugs of the j-compositions for the treatment of systemic infections (imipenem + cilastatin, ciprofloxacin)
Contract notice: Framework agreement for the supply of pharmaceutical active ingredients azacitidine, fingolimod, abacavir / lamivudine pavilizumab, imipenem cilastatin, interferon beta 1 a, doxorubicin liposomes and dexmedetomidine for the general hospital of la palma.
Prior Information Notice: Framework agreement for the supply of pharmaceutical active principles azacytidine, fingolimod, abacavir / lamivudine pavilizumab, imipenem cilastatin, interferon beta 1a, doxorubicin liposomes and dexmedetomidine for the general hospital of la palma.
Imipenem + cilastatin (500 +500) mg for intravenous administration,
Tenders are invited for Purchase of injuection imipenem 500 mg with cilastatin 500mg vial & inj.
Framework agreement with a single operator per lot for provision of medicines Ertapenem (DOE), colistimethate sodium (DOE), Tirofiban (DOE), Cefepime (DOE), imipenem / cilastatin (DOE) and Antiretrovirals in combination lamivudine (DOE) / Zidovudine (DOE).
Contract awarded for the university of chile, for hospital of the university of chile, hereinafter and indistinctly the "hospital", establishment of medical teaching and service high complexity calls tender for the acquisition by the delivery system of imipenem cilastatin 500 mg, which is governed by these rules.