ciclosporin


Also found in: Dictionary, Encyclopedia, Wikipedia.
Related to ciclosporin: tacrolimus

ciclosporin

ciclosporin (cyclosporine) 

An immunosuppressant used in the treatment of the ocular manifestation of autoimmune diseases, uveitis, scleritis, keratoconjunctivitis sicca, ligneous conjunctivitis, and to prevent rejection of corneal grafts, etc. It is believed to exert its immunosuppressive effect by inhibiting the activation of cytotoxic T-lymphocytes. See immunosuppressants.
References in periodicals archive ?
18) Ciclosporin prevents activation of T-lymphocytes and may also affect keratinocytes, while acitretin is a retinoic acid that suppresses keratinocyte proliferation.
This work was supported by a grant from Hospital and Homes of St Giles as part of the ciclosporin studies.
However, ciclosporin may be considered as an option for controlling the disease.
Are switches from oral to subcutaneous methotrexate or addition of ciclosporin to methotrexate useful steps in a tight control treatment strategy for rheumatoid arthritis?
The team evaluated results from 33 patients who were treated with prednisolone and chlorambucil, 37 patients with ciclosporin and 38 who were provided with supportive therapy alone.
Whether or not ciclosporin, a known risk factor for development of PTLD, played a part in the initial development of our patient's disease is also open to conjecture.
Edmonds EVJ, Morris SD, Short K, Bewley SJ, Eady RAJ: Pustular psoriasis of pregnancy treated with ciclosporin and high dose prednisolone.
5 mg/kg per day of ciclosporin or methotrexate plus placebo-ciclosporin.
The introduction of ciclosporin in the mid 1980s was a major advance, leading to 1-year survival rates of more than 90% and graft survival of 80%.
Risk factors for gingival overgrowth in patients medicated with ciclosporin in the absence of calcium channel blockers.
Fujita said he was inspired by the discovery of ciclosporin, also derived from a fungus, which spurred research into how the immune system may be subdued in transplant patients.