cicatricial pemphigoid


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Related to cicatricial pemphigoid: Ocular Cicatricial Pemphigoid

cicatricial pemphigoid

Etymology: L, cicatrix, scar; Gk, pemphix, blister or bubble + eidos, form
a benign, chronic, usually bilateral, subepidermal blistering disease chiefly involving the mucous membranes, especially those of the mouth and eye. It heals by scarring and may lead to slow shrinkage of the affected tissues, and to blindness if untreated. Also called benign mucosal pemphigoid.
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Cicatricial pemphigoid

cic·a·tri·cial pem·phi·goid

(sik'ă-trish'ăl pem'fi-goyd)
A chronic disease that produces adhesions and progressive cicatrization and shrinkage of the conjunctival, oral, and vaginal mucous membranes.

pemphigoid, cicatricial 

A rare, idiopathic, chronic systemic disease, most commonly of the elderly and characterized by recurrent blisters and bullae of the skin and mucous membranes, with subsequent scarring and shrinkage. The disease may affect only the conjunctiva (ocular pemphigoid). In this case, the clinical picture is a conjunctivitis with hyperaemia, mucous discharge and small vesicles, which on bursting result in ulceration, pseudomembranes, conjunctival subepithelial fibrosis and conjunctival shrinkage. The disease may give rise to adhesion between the palpebral and bulbar conjunctiva (symblepharon), ankyloblepharon, xerophthalmia, keratoconjunctivitis sicca, entropion, trichiasis and dry eye with corneal ulcer. There is pain or irritation and blurred vision. Treatment includes corticosteroids, surgery for entropion and trichiasis, and keratoprosthesis if vision is affected. Syn. benign mucous pemphigoid. See pseudomembranous conjunctivitis; Stevens-Johnson syndrome; ocular ferning test.

be·nign mu·cous mem·brane pem·phi·goid

(bĕ-nin myūkŭs membrān pemfi-goyd)
Blistering disease chiefly involving the subepidermal mucous membranes of mouth and eye (ocular pemphigus); usually chronic, benign, and typically bilateral. Scarring can occur and may lead to progressive shrinkage and tightening of the affected mucous membranes and connective tissues.
Synonym(s): cicatricial pemphigoid, ocular cicatricial pemphigoid.

cicatricial pemphigoid (sikətrishəl pem´figoid´),

pemphigoid

1. resembling pemphigus.
2. a group of skin disorders similar to but clearly distinguishable from pemphigus.

bullous pemphigoid
an autoimmune disease of skin and oral mucosa with vesicles, bullae and ulcerations; occurs rarely in dogs and humans.
cicatricial pemphigoid
a form that involves the oral and ocular mucosa.
References in periodicals archive ?
Pure ocular cicatricial pemphigoid is a unique clinical and immunopathological entity distinct from bullous pemphigoid and other subsets identified by antigenic specificity of autoantibodies," Archives of Dermatology, vol.
Kirtschig G, Marinkovich MP, Burgeson RE, Yancey KB: Anti-basement membrane autoantibodies in patients with anti-epilegrin cicatricial pemphigoid bind the alpha subunit of laminin subunit of laminin 5.
Topical tacrolimus for oral cicatricial pemphigoid.
The differential diagnosis included Behcet's disease, cicatricial pemphigoid, a fixed drug reaction, and allergic contact dermatitis.
She said it does not scar except in vulvovaginal areas, where it can lead to disfigurements similar to cicatricial pemphigoid.
Patients with cicatricial pemphigoid or mucous membrane pemphigoid have benefited from IVIg.
In yet another group of patients, mucin deficiency due to Stevens-Johnson syndrome or ocular cicatricial pemphigoid is the underlying mechanism of dry eye.
Sacher C, Hunzelmann N: Cicatricial pemphigoid (mucous membrane pemphigoid): current and emerging therapeutic approaches.
The common condition was cicatricial pemphigoid, which is a nonspecific skin disease that can affect mucous membranes in the eyes, mouth, vagina, and vulva.
Cicatricial pemphigoid is a vesiculobullous disease of the skin that may be found in the oral cavity.
These include pemphigus vulgaris (PV),pemphigus foliaceous (PF), pemphigus herpetiformis, bullous pemphigoid (BP),linear bullous dermatosis (LAD), cicatricial pemphigoid (CP), epidermolysis bullosa acquisita(psoriasis bullosa acquisita) and a novel bullous dermatosis targeting 200kDa molecule present in the lower lamina lucida.