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chymopapain

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chymopapain /chy·mo·pa·pain/ (ki″mo-pah-pān´) a cysteine endopeptidase from the tropical tree Carica papaya; it catalyzes the hydrolysis of proteins and polypeptides with a specificity similar to that of papain and is used in chemonucleolysis.
chy·mo·pa·pa·in (km-p-pn, -pn)
n.
A proteolytic enzyme obtained from the fruit of a tropical tree resembling papain; it is used in the treatment of herniated intervertebral disks.

Chymopapain
An enzyme from the milky white fluid of the papaya, used for medical purposes in chemonucleolysis.
Mentioned in: Chemonucleolysis

chymopapain
[kī′mōpəpā′ēn]
Etymology: Gk, chymos + Sp, papaya
a proteolytic enzyme isolated from the fruit of Carica papaya and related to papain. It is used in the treatment of prolapsed intervertebral or herniated disks.

chymopapain
a proteolytic enzyme (a sulfhydryl proteinase) from the tropical tree Carica papaya, used in chemonucleolysis.


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One hundred eighty-six of 327 patients without nonorganic signs, in contrast, were free of pain or had minimal limitations in activity following the chymopapain injection.
This cost-effectiveness issue has been examined empirically by Norton (1986), who studied the costs of surgical disc removal by both excision and use of chymopapain (an enzymatic lytic agent) in workers' compensation claimants in Oregon.
This first attempt to define prevalence rates of papain hypersensitivity in people with allergies is significant for its possible relationship to chemonucleolysis--the injection of chymopapain to dissolve herniated lumbar disks.
 
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