chymopapain


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chymopapain

 [ki″mo-pah-pān´]
a proteolytic enzyme from the tropical tree Carica papaya, used in chemonucleolysis of a herniated disk in the lumbar region.

chy·mo·pa·pa·in

(kī'mō-pap-ā'in),
A cysteine proteinase similar to papain in specificity; on rare occasions, it is used to shrink herniated intervertebral discs as an alternative to surgery; used as a meat tenderizer. It is the major endopeptidase of papaya.

chymopapain

/chy·mo·pa·pain/ (ki″mo-pah-pān´) a cysteine endopeptidase from the tropical tree Carica papaya; it catalyzes the hydrolysis of proteins and polypeptides with a specificity similar to that of papain and is used in chemonucleolysis.

chymopapain

(kī′mō-pə-pā′ĭn, -pī′ĭn)
n.
A proteolytic enzyme that is obtained from unripe papaya fruits and is similar to papain. It was formerly used in the United States to treat herniated intervertebral disks.

chymopapain

[kī′mōpəpā′ēn]
Etymology: Gk, chymos + Sp, papaya
a proteolytic enzyme isolated from the fruit of Carica papaya and related to papain. It is used in the treatment of prolapsed intervertebral or herniated disks.

Chymopapain

An enzyme from the milky white fluid of the papaya, used for medical purposes in chemonucleolysis.
Mentioned in: Chemonucleolysis

chymopapain

a proteolytic enzyme (a sulfhydryl proteinase) from the tropical tree Carica papaya, used in chemonucleolysis.
References in periodicals archive ?
Despite the apparent efficacy of chemonucleolysis with chymopapain in open uncontrolled trials, it was not until 1978 that results from double-blind, placebo-controlled trials were published.
In each instance, a set dose of chymopapain was injected by standard technique and compared with standard discectomy.
Chymopapain chemonucleolysis versus surgical discectomy in a military population.
Brocklehurst K, Salih E (1984) Fresh non-fruit of Carica papaya contains papain, multiple forms of chymopapain A and papaya proteinase [OMEGA].
This first attempt to define prevalence rates of papain hypersensitivity in people with allergies is significant for its possible relationship to chemonucleolysis--the injection of chymopapain to dissolve herniated lumbar disks.
Cross-reactivity between papain and chymopapain has not been proven by laboratory studies.
CHEMONUCLEOLYSIS: With derivation of chymopapain enzyme from papaya fruit in 1940, experiments to use it for scientific benefit were conducted in 1963, Smith et al (1) used its dehydrating effect in treatment of discogenic pain-Injecting the drug into the nucleus pulposus of the painful bulging disc caused the disc to lose its turgidity and shrink as a result of depolymerization of the proteoglycan and glycoprotein molecules in the nucleus pulposus--this 'shrinking effect' causes the disc to reduce in its height and girth, relieving pressure on the traversing neural component-the source of pain.
Spinal Therapies, White Bear Lake, MN Reintroducing CHYMOPAPAIN, the only proven minimally-invasive therapy for herniated discs; allows nuclear regeneration
Patients with allergies to papain, chymopapain, other papaya extracts, or the pineapple enzyme bromelain may also be at risk for an allergic reaction to CroFab(TM).
2 f e rol ular 345 They contain enzymes such as papain and chymopapain to help reduce inflammation.
According to the journal article, the Nucleoplasty procedure offers the advantages of earlier disc decompression techniques, such as Chymopapain and laser discectomy, and "may not have the associated complications and side effects of these previously performed techniques.