chylomicron


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Related to chylomicron: Chylomicron Retention Disease

chylomicron

 [ki″lo-mi´kron]
a particle of the class of lipoproteins responsible for the transport of exogenous cholesterol and triglycerides from the small intestine to tissues after meals. Chylomicrons are spherical particles with a core of triglycerides surrounded by a layer of phospholipids, cholesterol, and apolipoproteins.

chy·lo·mi·cron

, pl.

chy·lo·mi·cra

,

chy·lo·mi·crons

(kī'lō-mī'kron, -mī'kră, -mi'kronz),
A large lipid droplet (up to 100 mm in diameter) of reprocessed lipid synthesized in epithelial cells of the small intestine and containing triacylglycerols, cholesterol esters, and several apolipoproteins (for example, A-I, B-48, C-I, C-II, C-III, E); the least dense (less than 1.006 g/mL) of the plasma lipoproteins that function as transport vehicles.
[chylo- + G. micros, small]

chylomicron

/chy·lo·mi·cron/ (-mi´kron) a class of lipoproteins that transport exogenous (dietary) cholesterol and triglycerides after meals from the small intestine to tissues for degradation to chylomicron remnants.

chylomicron

(kī′lō-mī′krŏn′)
n.
A lipoprotein formed in the small intestine that transports dietary fats and cholesterol through the lymphatic system to the bloodstream. Chylomicrons are larger and less dense than very-low-density lipoproteins.

chylomicron

[kī′lōmī′kron]
Etymology: Gk, chylos + mikros, small
minute lipoproteins measuring less than 0.5 μm in diameter. Chylomicrons consist of about 90 triglycerides with small amounts of cholesterol, phospholipids, fat-soluble vitamins, and protein. They are synthesized in the GI tract and carry dietary fat from the intestinal mucosa via the thoracic lymphatic duct into the plasma and ultimately to the liver and tissues. The remnant chylomicron particles are removed by the liver.

chy·lo·mi·cron

, pl. chylomicra, pl.chylomicrons (kī'lō-mī'kron, -kră,-kronz)
A droplet of reprocessed lipid synthesized in epithelial cells of the small intestine; the least dense of the plasma lipoproteins.
[chylo- + G. micros, small]

chylomicron

the form in which fat is transported from the gut to the rest of the body, consisting of a lipid core surrounded by an envelope of protein, cholesterol and phospholipid. Chylomicrons are around 100 nm across and are formed in the intestinal mucosa, from where they enter the LACTEALS and eventually the bloodstream.

chylomicron

a stable droplet containing principally triglyceride fat, but also cholesterol, phospholipids and protein; found in intestinal lymphatics (lacteals) and blood during and after meals.

chylomicron test
in chilled serum, chylomicrons rise to form a creamy top layer and the serum clears; very low-density lipoproteins remain dispersed and the serum is turbid. Called also the refrigeration test.
References in periodicals archive ?
The sieve's place in the treatment of septic shock syndrome (due to TNF alpha and other inflammatory cytokines) from endotoxin activation of the reticulo-endothelial system, especially the liver macrophages (Kuppfer cells) being negated by infusion of chylomicrons (21).
We found no effect of chronic black tea ingestion on the plasma concentrations of chylomicrons and chylomicron remnants as indicated by apoB-48 levels in healthy human subjects.
Differences in postprandial concentrations of very-low-density lipoprotein and chylomicron remnants between normotriglyceridemic and hypertriglyceridemic men with and without coronary heart disease.
Prior to therapy, all patients exhibited poor post-meal chylomicron handling as measured by amount seen in the plasma over 9 hours following meal ingestion.
This area of posterior parietal pericardial dissection around the paired pulmonary veins could allow a path of ingress of posterior mediastinal, peribronchial lymph to the pericardial space; absorbed oral fat in the form of chylomicrons could then enter into the pericardial space in this fashion.
In patients with mutations in the LPL gene, dietary fat (triglyceride molecules) cannot be broken down and so causes chylomicrons, which carry triglycerides around the body, to accumulate in the blood.
The chylomicron remnant, containing mainly cholesteryl esters, then travels back to the liver.
The human apolipoprotein E (apo E) is a serum glycoprotein consisting of 299 amino acids found in circulating chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL), intermediate density lipoproteins (IDL) and high-density lipoproteins (HDL) (1).
Double-blind controlled study on the effects of dietary diacylglycerol on post-prandial serum and chylomicron triacylglycerol responses in healthy humans.
These particles are released into the lymph in the thoracic duct, finally ending up in the liver where the chylomicron particle is disintegrated and the content is used in the synthesis of non-polar lipids such as triglycerides and cholesteryl esters.
Upon treating cultured human intestinal cells with oleic acid, the research team observed significant secretion of LPS together with the chylomicron particles, a phenomenon that was not observed when the cells were treated with short-chain butyric acid.