When comparing the two compounds in this study, greater chronotropic
activity as was seen with arbutamine, appeared to be the major determinant of induced ischemia.
When only chronotropic
and dromotropic effects are used as markers, the effects of fibers projecting on to atrial tissue remote from the sinus node or the AV node may be overlooked.
In the positive control, NE showed both positive inotropic and positive chronotropic
effects in a concentration-dependent manner.
In these preparations, OEMV had negative inotropic and chronotropic
effects, which were concentration-dependent.
The results demonstrated that dobutamine exhibited substantial proarrhythmic and chronotropic
effects in patients with no existing arrhythmia and with pre-existing arrhythmia, whereas nesiritide actually either reduced these effects or had a neutral effect.
They are formed in accordance with difference of the impulse speed on the sympathetic and parasympathetic nerves, as well as influences of active substances concentrations in tissue environment on HRV fluctuations, acting directly upon chronotropic
function of the SN pacemaker cells.
response to exercise in patients with atrial fibrillation.
Human or salmon calcitonin has no significant effects on blood pressure (18) but salmon calcitonin induces negative chronotropic
and negative inotropic effects on isolated dog atrium (19), suggesting that it has a possible role in the regulation of myocardial contractile force and rate.
Nasa Y, Ichihara K, Yoshida R, Abiko Y (1992) Positive inotropic and negative chronotropic
effect of (-)-cis-diltiazem in rat isolated atria.
In physiological doses NO results in positive inotropic, positive chronotropic
and positive lusinotropic effects in myocardium.
Caution is taken because HCM patients may already be limited by chronotropic
incompetence before medication; high doses of [beta]-blockers may exacerbate or cause fatigue and worsen exercise tolerance (50).
1979) reported that tetramethylpyrazine phosphate produced positive inotropic and chronotropic
effects on the heart and some direct dilating action on peripheral blood vessels in anesthetized dogs.