chronotherapy


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chro·no·ther·ap·y

(kron'ō-thār'ă-pē),
The practice of administering chemotherapy at certain times of the day that are thought to be optimal for enhanced activity or lessened toxicity.
See also: chronooncology.
[chrono- + therapy]

chronotherapy

(krŏn′ō-thĕr′ə-pē, krō′nə-)

chronotherapy

Any therapy based on the timing of physiologic and pathologic events.

Alternative medicine
The process in which a person’s daily activities are supposedly synchronised with a natural metabolic rhythm in a 24-hour cycle. Chronotherapy establishes routines of exercise, eating, work, study, rest and sleep.

Oncology
The adminstration of chemotherapy doses synchronised to the body’s circadian rhythm. Chronotherapy may increase allowable doses of chemotherapeutics, while decreasing tumour burden and chemotherapy-related side effects.

Chronotherapeutics, core concepts
▪ Predictable pattern—Bioperiodic variation in manifestations of disease that are common to all individuals.
▪ Individual pattern—Variations in chronokinetics unique to one person.
 
Chronotherapeutics, relevance
▪ Variation in intensity of symptoms over time—e.g., allergic rhinitis, angina, asthma, MI, postsurgical pain, ulcer disease.
▪ Where therapeutic-to-toxic ratio varies predictably—e.g., chemotherapy.
▪ Where pharmacokinetics are known to be biologic rhythm-dependent—e.g., antihistamines, antihypertensives, heparin, NSAIDs.
▪ Where hormonal manipulation is intended to simulate the normal temporal ebb-and-flow hormone levels—e.g., insulin in IDDM, corticosteroid and luteinising hormone-releasing hormone.

chronotherapy

Any therapy based on the timing of physiologic and pathologic event. See Bright light therapy, Chronobiology, Circadian rhythm, Seasonal affective disorder Oncology The adminstration of chemotherapy doses synchronized to the body's circadian rhythm; CT may ↑ allowable doses of chemotherapeutics, ↓ tumor burden, and chemotherapy-related side effects.
References in periodicals archive ?
On the other hand the study revealed an improved HPA axis responsiveness in patients with RA who were administered prednisolone chronotherapy compared to conventional morning prednisolone treatment25 and this specific effect is the cause of improved symptom control as compared to morning prednisolone.
he is attempting to establish if chronotherapy is less toxic and therefore less harmful to patients but more effective depending on the time-of-day they are administered.
Randomised multicentre trial of chronotherapy with oxaliplatin, fluorouracil, and folinic acid in metastatic colorectal cancer.
Another form of chronotherapy focuses on exposure to darkness, and it is particularly useful in bipolar disorder, mostly in manic patients.
The Block Center is the first US medical clinic to use a portable, computerized, FDA-approved pump to administer chronotherapy.
Treatment of sleep problems includes various behavioral methods, such as stimulus control and sleep hygiene, extinction, sleep restriction, bedtime fading and chronotherapy.
This linkage is important for a new field of research and medicine known as chronotherapy, which aims to coordinate the delivery of chemotherapeutic drugs with the circadian and cell cycles to maximize drug efficacy while minimizing side effects.
Once considered an emerging field, chronotherapy - diagnosis and treatment based on the body's biological rhythms - is now used to treat a range of ailments, from sleep disorders to depression, and even, in some cases, cancer.
According to experts on chronotherapy - the science of taking drugs to fit in with the body clock - osteoarthritis sufferers should take their drugs mid-afternoon while rheumatoid arthritis sufferers should take theirs shortly before going to bed.
Joan Roberts (Fordham University) listed hormones that our body produces during periods of light and darkness, and showed how studies are leading to the development of chronotherapy, the coordination of treatment with the time of day.
Patented technology developed by Purdue has yielded such benefits as programmed chronotherapy, prolonged effectiveness and better patient compliance.