chronotherapy


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chro·no·ther·ap·y

(kron'ō-thār'ă-pē),
The practice of administering chemotherapy at certain times of the day that are thought to be optimal for enhanced activity or lessened toxicity.
See also: chronooncology.
[chrono- + therapy]

chronotherapy

(krŏn′ō-thĕr′ə-pē, krō′nə-)

chronotherapy

Any therapy based on the timing of physiologic and pathologic events.

Alternative medicine
The process in which a person’s daily activities are supposedly synchronised with a natural metabolic rhythm in a 24-hour cycle. Chronotherapy establishes routines of exercise, eating, work, study, rest and sleep.

Oncology
The adminstration of chemotherapy doses synchronised to the body’s circadian rhythm. Chronotherapy may increase allowable doses of chemotherapeutics, while decreasing tumour burden and chemotherapy-related side effects.

Chronotherapeutics, core concepts
▪ Predictable pattern—Bioperiodic variation in manifestations of disease that are common to all individuals.
▪ Individual pattern—Variations in chronokinetics unique to one person.
 
Chronotherapeutics, relevance
▪ Variation in intensity of symptoms over time—e.g., allergic rhinitis, angina, asthma, MI, postsurgical pain, ulcer disease.
▪ Where therapeutic-to-toxic ratio varies predictably—e.g., chemotherapy.
▪ Where pharmacokinetics are known to be biologic rhythm-dependent—e.g., antihistamines, antihypertensives, heparin, NSAIDs.
▪ Where hormonal manipulation is intended to simulate the normal temporal ebb-and-flow hormone levels—e.g., insulin in IDDM, corticosteroid and luteinising hormone-releasing hormone.

chronotherapy

Any therapy based on the timing of physiologic and pathologic event. See Bright light therapy, Chronobiology, Circadian rhythm, Seasonal affective disorder Oncology The adminstration of chemotherapy doses synchronized to the body's circadian rhythm; CT may ↑ allowable doses of chemotherapeutics, ↓ tumor burden, and chemotherapy-related side effects.
References in periodicals archive ?
Low-dose prednisone chronotherapy for rheumatoid arthritis: a randomised clinical trial (CAPRA-2).
The Block Center is the first US medical clinic to use a portable, computerized, FDA-approved pump to administer chronotherapy.
According to experts on chronotherapy - the science of taking drugs to fit in with the body clock - osteoarthritis sufferers should take their drugs mid-afternoon while rheumatoid arthritis sufferers should take theirs shortly before going to bed.
Randomized multicenter trial of chronotherapy with oxaliplatin, fluorouracil, and folinic acid in metastatic colorectal cancer.
Chronotherapy is the relatively new practice of timed treatment.
Chronotherapy, whether by chemical or physical agent, is concerned with achieving maximum benefit for the patient by providing treatment according to the body's time structure.
Triple Chronotherapy offers the most rapid treatment for depression
Crucially, we administered the chemo through chronotherapy via an FDA-approved portable pump, small enough to fit in a fanny pack, which delivered supplemental intravenous nutrients at the same time as the chemo drug.
Because the term 'sleep disorder' encompasses such a broad range of disorders there is a range of approaches to the treatment of sleep disorders, including basic explanation of environmental and lifestyle factors that can affect sleep; behavioral techniques, which aim to teach the child appropriate sleep habits and/or to correct inappropriately learnt behaviour; cognitive therapy; chronotherapy (altering sleep timing in specific, systematic ways to re-set the body clock); physical measures such as using bright light to alter sleep times; or using aids such as nasal continuous positive airways pressure (NCPAP) to aid breathing during sleep; surgery (e.
According to experts in chronotherapy - a revolutionary new area of medicine which looks at the effect time has on the human body - there are certain hours of the day when it's much easier to exercise, other times when your brain is better at dealing with mental tasks, and even times when it's better to take certain medications.
Researchers are now making the leap from chronobiology, the study of these basic rhythms, to chronotherapy, the tailoring of drugs to the rhythms of the body and of disease.
Glucocorticoid Chronotherapy with Delayed-Release Prednisone