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Timing of dosage of medication according to the circadian rhythms attached to the given disease.
See also: chronotherapy.


(krŏn′ō-thĕr′ə-pyo͞o′tĭks, krō′nə-)
n. (used with sing. verb)
1. Medical treatment administered according to a schedule that corresponds to a person's daily, monthly, seasonal, or yearly biological clock, in order to maximize the health benefits and minimize adverse effects.
2. Treatment of a sleep disorder by altering an individual's sleeping and waking times and resetting his or her biological clock. In both senses also called chronotherapy.


a branch of medicine concerned with effects of circadian rhythms in human health, such as the hour of the day when asthma symptoms or heart attacks are most likely to occur, the best time of day for treating certain complaints, and the best times to administer medication or chemotherapy to enhance activity or lessen toxicity. Practitioners of chronotherapeutics also believe that there is a best time of the month for performing breast cancer surgery and that cholesterol levels are higher and heart attacks are more common during the winter months.


Any therapy based on the timing of physiologic and pathologic events.

Alternative medicine
The process in which a person’s daily activities are supposedly synchronised with a natural metabolic rhythm in a 24-hour cycle. Chronotherapy establishes routines of exercise, eating, work, study, rest and sleep.

The adminstration of chemotherapy doses synchronised to the body’s circadian rhythm. Chronotherapy may increase allowable doses of chemotherapeutics, while decreasing tumour burden and chemotherapy-related side effects.

Chronotherapeutics, core concepts
▪ Predictable pattern—Bioperiodic variation in manifestations of disease that are common to all individuals.
▪ Individual pattern—Variations in chronokinetics unique to one person.
Chronotherapeutics, relevance
▪ Variation in intensity of symptoms over time—e.g., allergic rhinitis, angina, asthma, MI, postsurgical pain, ulcer disease.
▪ Where therapeutic-to-toxic ratio varies predictably—e.g., chemotherapy.
▪ Where pharmacokinetics are known to be biologic rhythm-dependent—e.g., antihistamines, antihypertensives, heparin, NSAIDs.
▪ Where hormonal manipulation is intended to simulate the normal temporal ebb-and-flow hormone levels—e.g., insulin in IDDM, corticosteroid and luteinising hormone-releasing hormone.


Timing of dosage of medication according to the circadian rhythms attached to the given disease.
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References in periodicals archive ?
In clinical practice, there is still rather widespread ignorance about circadian sleep disturbances and chronotherapeutics in spite of the significant evidence base," she said.
For more information on chronotherapeutics, check out the Center for Environmental Therapeutics' Website at www.
Far more advanced, however, is a chronotherapeutic prednisone formulation that is referred to in the United States as "delayed-release prednisone" (DR prednisone) and in Europe as "modified-release prednisone" (MR prednisone); these are interchangeable terms that refer to the same drug.
S lithium, a first-line mood stabilizer with evidence of usefulness in treatment before chronotherapeutic interventions and in preventing suicidal behavior.