chronic toxicity


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chronic toxicity

Toxicology A condition caused by repeated or long-term exposure to low doses of a toxic substance
References in periodicals archive ?
1971) carried out a toxicological study in rats and dogs for the detection of chronic toxicity on application of high doses of a combination product with synthetical D,L-kavain (Hapke et al.
The researchers were selected for the award because their collaborative efforts have contributed new knowledge about how the human brain responds and adapts to the chronic toxicity of excessive alcohol consumption.
A question from the Committee on Science to the EPA, "Regarding emissions of hydrofluosilicic acid, which EPA has characterized as a water and air pollutant, how does EPA explain its willingness to allow this substance to be bled into drinking water systems (especially in the absence of any chronic toxicity studies on it).
The financing will also allow Aquinox to complete chronic toxicity studies as well as large-scale manufacturing of AQX-1125.
The team used EPA Region III's chronic toxicity index, which combines total mass released with toxicity factors including carcinogenic weight of evidence and cancer potency factors.
Relative to a therapeutically administered drug, the acute and/or chronic toxicity usually follows the pharmacologic effect, if it is to occur.
This management consisted of oversight and monitoring of acute and chronic toxicity studies.
Services include toxicology (acute, subchronic, and chronic toxicity, reproductive toxicity, genetic toxicology, and carcinogenicity), pharmacokinetics, toxicokinetics, bioavailability, ADME, chemical characterization, impurities analysis and synthesis, bioanalytical, microbiology, and full in vitro toxicology and immunology services.
To comparatively rank TRI chemical releases, we adapted the chronic toxicity index developed by the U.
Chronic toxicity was studied in rats treated daily with an oral dose of 2 ml/kg body wt.
One key requirement is that the institution explore new applications for the Microtox Chronic Toxicity Test and report on the work, contributing to the technical literature on the technology.

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