chronic sclerosing sialadenitis

chronic sclerosing sialadenitis

An uncommon unilateral inflammatory condition affecting the submandibular gland, which may mimic neoplasia.
 
Aetiology
Idiopathic, stones, microliths, infection, immune-related, linked to reduced salivary flow, increased viscosity. Long-standing obstruction causes inflammation leading to acinar atrophy and fibrosis. The most extreme manifestation of this process is the so-called Kuttner tumour—a rock-hard, tumour-like areas of end-stage fibrosis and lymphoplasmacytic inflammation, which may be accompanied by metaplasia (squamous, mucous, ciliated, oncocytic) in the ducts.

DiffDx
Lymphoma, lymphoepithelial lesion.
References in periodicals archive ?
In addition to the pulmonary lesions, increased numbers of IgG4-positive plasma cells were present in regional nodes and in areas of chronic sclerosing sialadenitis of 1 patient.
Chronic sclerosing sialadenitis often exclusively involves the submandibular gland, occasionally with a bilateral presentation.
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