chronic renal failure


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chronic renal failure (CRF)

gradual loss of kidney function, with progressively more severe renal insufficiency until the stage called chronic irreversible kidney failure or end-stage renal disease. Symptoms may include polyuria, anorexia or nausea, dehydration, and neurological symptoms. See also renal failure.

chronic renal failure

A spectrum of severe renal diseases ranging from non-dialysis-dependent chronic kidney disease in patients don’t require renal replacement therapy (i.e., dialysis or renal transplant), to those with end-stage kidney disease who do.

Aetiology
Diabetes, hypertension, glomerulonephritis.

Clinical findings, external
Dehydration, oedema, anaemia, sallow colour, pruritis, brown discolouration of nails, bruising (abnormal platelets); other findings may include cutaneous vasculitic lesions, diabetes, peripheral vascular disease, spina bifida or other causes of neurogenic bladder.

Clinical findings, internal
Hypertension, heart failure, pulmonary oedema, pleural effusions, pericardial effusion, GI bleeding due to peptic ulceration, gastritis/oesophagitis/colitis, acute pancreatitis.

Cause of death, chronic renal failure
Uraemia:
• Convulsions;
• Coma;
• Cardiac myocyte dysfunction;
• Congestive heart failure;
• Pericarditis;
• Pericardial effusion;
• Arrhythmias;
• Tamponade;
• Left ventricular hypertrophy;
• Coronary artery disease.
Tumours:
• Renal cell carcinoma;
• Lymphomas;
• Hepatocellular carcinoma;
• Thyroid carcinoma.

chronic renal failure

Chronic kidney failure Nephrology A slow decline in renal function, which may be 2º to chronic HTN, DM, CHF, SLE, or sickle cell anemia and, if extreme, leads to ESRD, mandating kidney dialysis; an abrupt decline in renal function may be triggered by acute intercurrent processes–eg, sepsis, shock, trauma, kidney stones, kidney infection, drugs–aspirin or lithium, toxins, abuse substances, or injection of iodinated radiocontrast Lab Fluid retention, uremia Management Low-protein diet to conserve renal function; transplantation if ESRD
References in periodicals archive ?
Deafness may be reversible in some patients with chronic renal failure who undergo hemodialysis, so a prolonged follow-up is necessary.
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We are pleased to have received this award, which recognizes our strategic alliance with Takeda to develop Hematide worldwide as a potential treatment for anemia associated with chronic renal failure and cancer," said Arlene M.
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Eric Cohen, MD of the Medical College of Wisconsin in Milwaukee said that currently 5-15% of all patients undergoing BMT may develop acute renal failure, and of long-term BMT survivors, 5-20% will develop chronic renal failure.
Kaye said the research compared the length of time it takes for the drug to work its way through the systems of patients undergoing chemotherapy and those with chronic renal failure.
Although the double-substrate phenotyping method used in the present study could conceivably give misleading information if chronic renal failure were to alter the reactivity of paraoxonase to either substrate, this seems unlikely.
Trial to target malnutrition in chronic renal failure patients
His research interests include the pathogenesis and treatment of acute and chronic renal failure.
We are very pleased with the arbitrators' decision and now look forward to focusing our efforts on the continued development of this promising new drug to treat patients suffering from the debilitating effects of anemia associated with chronic renal failure, cancer and other diseases,'' Gordon Binder, Amgen's chairman and chief executive officer, said in a statement.
Tenders are invited for Purchase Agreement Framework National Programme Drug Required Alternate Renal Function in Patients with Chronic Renal Failure

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