chronic pancreatitis


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chron·ic pan·cre·a·ti·tis

recurrent bouts of inflammatory disease of the pancreas characterized by fibrosis and varying degrees of irreversible loss of exocrine and ultimately endocrine function.

chronic pancreatitis

Etymology: Gk, chronos, time, peri, near, teinein-all, kreas, flesh, itis, inflammation
chronic inflammation of the pancreas with fibrosis and calcification of the gland. It may follow repeated acute attacks and can lead to diabetes. Causes include alcohol abuse, genetic diseases such as cystic fibrosis, and conditions obstructing the pancreatic duct.
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Chronic pancreatitis

chronic pancreatitis

A condition characterised by inflammation of the pancreas.

Risk factors
Alcohol abuse, cystic fibrosis, gallstones, pancreas divisum, drugs/medication.

Clinical findings
Abdominal pain, malabsorption, secondary diabetes.

Types
Autoimmune, familial, SPINK mutation-related.

Aetiology
Alcohol, nutritional, hereditary (e.g, cystic fibrosis), protein defects, idiopathic, trauma, hypercalcaemia.

Complications
Pseudocyst formation.

chronic pancreatitis

Chronic relapsing pancreatitis GI disease Recurrent pancreatitis linked to alcohol abuse or hemochromatosis, which may worsen with time. See Pancreatitis.

pancreatitis

inflammation of the pancreas.

acute hemorrhagic pancreatitis
a condition due to autolysis of pancreatic tissue caused by escape of enzymes into the substance, resulting in hemorrhage into the parenchyma and surrounding tissues. Seen most commonly in dogs, rarely in horses and pigs. Clinical signs include abdominal pain that may be severe and associated with cardiovascular shock, vomiting and diarrhea. Fatalities are not uncommon. In the longer term, the process may be slowly progressive, appearing clinically to be relapsing, often with eventual destruction of the islets of Langerhans that leads to diabetes mellitus. Called also acute pancreatic necrosis.
chronic pancreatitis
relapsing or continuing acute pancreatic necrosis. Called also relapsing pancreatitis.
focal pancreatitis
focal lesions discovered incidentally in patients dying of other disease, e.g. canine distemper, foot and mouth disease.
interstitial pancreatitis
inflammation of the interstitial tissue; may be acute or chronic.
necrotizing pancreatitis
see acute hemorrhagic pancreatitis (above).
relapsing pancreatitis
see chronic pancreatitis (see above).

Patient discussion about chronic pancreatitis

Q. Where can I find a doctor specializing in Chronic Pancreatitis in New York City? Looking for a gastroenterologist that specializes in Chronic Pancreatitis or pancreatic diseases, who is known to be an "expert" in this field. If you also know of someone in New Jersey or Pennsylvania, that would be great too.

A. Here you are couple of sites about good Dr. you can find in NYC, this one is from the magazine “New York best doctors 2008”
http://www.castleconnolly.com/doctors/results.cfm?dws=wke&source=nymetro&speccode=018
and here is another site but this one requires registration if I’m not mistaken..
http://www.americastopdoctors.com/

More discussions about chronic pancreatitis
References in periodicals archive ?
Although, pancreatic intraepithelial neoplasia is considered a precursor lesion for pancreatic ductal adenocarcinoma, it may appear in non-neoplastic diseases such as acute or chronic pancreatitis [20].
118) Thus, the fibrosis of chronic pancreatitis has its origin in the inflammatory effect of macrophages on acinar cells.
Morphological Changes in the Pancreas from Acute to Chronic Pancreatitis
The results draw attention to the high health and financial impact of chronic pancreatitis in children, according to an editorial by Dr.
Normal or higher calcemia during acute or chronic pancreatitis should always draw attention and be subject to complementary explorations in search of endocrine or malignant cause.
Premucosal causes: Diseases related topre mucosal malabsorption are described below: Chronic pancreatitis: Chronic pancreatitis is an irreversible progressive disease characterized by destruction of the pancreatic secretory parenchyma that leads to fibrosis of the pancreatic tissue.
This flushing mechanism is significant in protecting the pancreas from premature activation of the proteases and self-digestion and thus from the development of recurrent acute and chronic pancreatitis.
In contrast, chronic pancreatitis is grossly characterized by uneven and poorly circumscribed fibrosis of the parenchyma, which usually involves the pancreas more diffusely than it does in PDAC and is often associated with calculi in the ducts and pseudocyst formations.
As severity of chronic pancreatitis increases, duct compliance falls, resulting in decreased secretin-induced dilation, typically coinciding with worsening duct irregularity and overall chronic dilation (Figure 4).
Factors associated with health-related quality of life in chronic pancreatitis.
Both acute and chronic pancreatitis are marked by mild to severe abdominal pain, often with nausea, vomiting, and fever; and, both can lead to severe complications (http://www.
Complications Number of Patients (n=56) Chronic Pancreatitis 25 Pancreatic Pseudocyst 17 Hypocalcemia 12 DM 5 ARDS 4 Acute Renal Failure 3 Pleural Effusion 3 Splenic Vein Thrombosis 2 Pancreatic Abscess 2 Ileus 1 Malabsorption 1 Figure 1: Causes of Acute Pancreatitis.

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