chronic pancreatitis


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chron·ic pan·cre·a·ti·tis

recurrent bouts of inflammatory disease of the pancreas characterized by fibrosis and varying degrees of irreversible loss of exocrine and ultimately endocrine function.

chronic pancreatitis

Etymology: Gk, chronos, time, peri, near, teinein-all, kreas, flesh, itis, inflammation
chronic inflammation of the pancreas with fibrosis and calcification of the gland. It may follow repeated acute attacks and can lead to diabetes. Causes include alcohol abuse, genetic diseases such as cystic fibrosis, and conditions obstructing the pancreatic duct.
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Chronic pancreatitis

chronic pancreatitis

A condition characterised by inflammation of the pancreas.

Risk factors
Alcohol abuse, cystic fibrosis, gallstones, pancreas divisum, drugs/medication.

Clinical findings
Abdominal pain, malabsorption, secondary diabetes.

Types
Autoimmune, familial, SPINK mutation-related.

Aetiology
Alcohol, nutritional, hereditary (e.g, cystic fibrosis), protein defects, idiopathic, trauma, hypercalcaemia.

Complications
Pseudocyst formation.

chronic pancreatitis

Chronic relapsing pancreatitis GI disease Recurrent pancreatitis linked to alcohol abuse or hemochromatosis, which may worsen with time. See Pancreatitis.

pancreatitis

inflammation of the pancreas.

acute hemorrhagic pancreatitis
a condition due to autolysis of pancreatic tissue caused by escape of enzymes into the substance, resulting in hemorrhage into the parenchyma and surrounding tissues. Seen most commonly in dogs, rarely in horses and pigs. Clinical signs include abdominal pain that may be severe and associated with cardiovascular shock, vomiting and diarrhea. Fatalities are not uncommon. In the longer term, the process may be slowly progressive, appearing clinically to be relapsing, often with eventual destruction of the islets of Langerhans that leads to diabetes mellitus. Called also acute pancreatic necrosis.
chronic pancreatitis
relapsing or continuing acute pancreatic necrosis. Called also relapsing pancreatitis.
focal pancreatitis
focal lesions discovered incidentally in patients dying of other disease, e.g. canine distemper, foot and mouth disease.
interstitial pancreatitis
inflammation of the interstitial tissue; may be acute or chronic.
necrotizing pancreatitis
see acute hemorrhagic pancreatitis (above).
relapsing pancreatitis
see chronic pancreatitis (see above).

Patient discussion about chronic pancreatitis

Q. Where can I find a doctor specializing in Chronic Pancreatitis in New York City? Looking for a gastroenterologist that specializes in Chronic Pancreatitis or pancreatic diseases, who is known to be an "expert" in this field. If you also know of someone in New Jersey or Pennsylvania, that would be great too.

A. Here you are couple of sites about good Dr. you can find in NYC, this one is from the magazine “New York best doctors 2008”
http://www.castleconnolly.com/doctors/results.cfm?dws=wke&source=nymetro&speccode=018
and here is another site but this one requires registration if I’m not mistaken..
http://www.americastopdoctors.com/

More discussions about chronic pancreatitis
References in periodicals archive ?
In humans, chronic pancreatitis has been implicated in 3-4% of pancreatic cancers (Maisonneuve and Lowenfels 1999, 2002).
Of the 6 patients with chronic pancreatitis (all of whom underwent operations), conventional real-time PCR revealed the presence of KRAS mutations in 2 cases, and digital PCR also identified 2 cases as positive.
As stated earlier, the risk of alcoholic acute and chronic pancreatitis increases with increasing intake of ethanol.
Factors associated with health-related quality of life in chronic pancreatitis.
Advances in understanding the mechanisms leading to chronic pancreatitis.
At EUS and ERCP abnormalities suggestive of chronic pancreatitis were more common in high-risk patients than in control subjects.
Diabetes mellitus can be a complication of acute and chronic pancreatitis, though why this happens has yet to await explanation, and not too many studies exist to show new insights.
Acting on the observation that oxidative stress has been implicated in the pathophysiology of chronic pancreatitis CP), the authors evaluated the effects of antioxidant supplementation on pain relief, oxidative stress and antioxidant status in patients with CP.
A localised, paralytic intestinal loop ('sentinel loop'), paucity of air in the colon distal to the splenic flexure due to functional spasm of the descending colon ('colon cut-off sign'), pancreatic calcifications as seen in chronic pancreatitis, blurred margins of the psoas muscles or calcified biliary concrements can be indirect signs of pancreatitis.
They are reported to occur in 10% of chronic pancreatitis cases, with a high mortality rate after rupture.
hospitals are associated with chronic pancreatitis.

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