chronic neutrophilic leukaemia
chronic neutrophilic leukaemiaA rare myeloproliferative disorder characterised by prominent neutrophilia in peripheral blood, myeloid hyperplasia in the bone marrow, hepatosplenomegaly and an absence of the Philadelphia chromosome or BCR/ABL fusion gene.
Hepatosplenomegaly; less commonly: pruritus, gout, mucocutaneous bleeding.
CML, neutrophilic-CML, myelodysplastic syndrome.
Hydroxyurea to control leukocytosis and reduce splenomegaly; chemotherapy.
Uncertain; patients die in blast transformation or with progressive leucocytosis.