chronic myelogenous leukemia


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chronic myelocytic leukemia

a heterogeneous group of myeloproliferative disorders that may evolve into acute leukemia in late stages (that is, blast crisis.)

chronic myelogenous leukemia

n.
Leukemia characterized by abnormally high levels of granulocytes in the blood and bone marrow and by the presence in most of these cells of an abnormal chromosome (the Philadelphia chromosome), occurring primarily in older adults and typically having a slow progression with early symptoms including fatigue and an enlarged spleen. Also called chronic granulocytic leukemia, chronic myelocytic leukemia, chronic myeloid leukemia.

chronic myelogenous leukemia

[mī′əlōsit′ik]
Myeloproliferative neoplasm characterized by the unregulated and excessive production of cells of the myelocytic maturation series and presence of the BCR/ABL 1 mutation. Compare acute lymphocytic leukemia, chronic lymphocytic leukemia, leukemoid reaction. See also acute myelocytic leukemia, chronic myelocytic leukemia, leukocytosis.

chron·ic my·e·lo·cyt·ic leu·ke·mi·a

(kron'ik mī'ĕ-lō-sit'ik lū-kē'mē-ă)
A heterogeneous group of myeloproliferative disorders that may evolve into acute leukemia in late stages (i.e., blast crisis). Slow onset, usually in olderadults.
Synonym(s): chronic granulocytic leukemia, chronic myelogenous leukemia, chronic myeloid leukemia.

Chronic myelogenous leukemia (CML)

Also called chronic myelocytic leukemia, malignant disorder that involves abnormal accumulation of white cells in the marrow and bloodstream.
References in periodicals archive ?
Clinical and prognostic features of patients with Philadelphia chromosome-positive chronic myelogenous leukemia and extramedullary disease.
Chronic myelogenous leukemia (CML): clonal hematopoietic stem cell disorder accounting for 15%--20% of all cases of adult leukemia
Despite imatinib's success against chronic myelogenous leukemia, recent studies have found that the drug loses its effectiveness in about one-fifth of patients (SN: 6/17/06, p.
GlobalData estimates that the global Chronic Myelogenous Leukemia (CML) therapeutics market was valued at $1,089m in 2005 and grew at a Compound Annual Growth Rate (CAGR) of 24% to reach $3,246m in 2010.
Otherwise, his medical history was significant for Philadelphia chromosome-positive chronic myelogenous leukemia, which had been treated with oral imatinib.
That changed when other scientists showed that the drug imatinib mesylate, or Gleevec, can thwart chronic myelogenous leukemia in animals and people by inhibiting another mutant tyrosine kinase (SN: 12/11/99, p.
The once-a-day-pill Glivec was used on 83 patients, including two San Fernando Valley residents, at the University of California, Los Angeles, in the first phase of chronic myelogenous leukemia, which strikes more than 10,000 people worldwide each year.
A new consistent chromosomal abnormality in chronic myelogenous leukemia identified by quinacrine fluorescence and Giemsa staining.
The 168 patients studied included persons with advanced-stage acute or chronic myelogenous leukemia or acute lymphocytic leukemia who had had 1 or more relapses, those with lymphomas refractory to treatment, and individuals with myelodysplasias.
Patent 7,728,131 for oncology drug candidate bafetinib, encompassing claims related to bafetinib's pharmaceutical compound and composition in all indications, as well as for use in methods for treating acute and chronic myelogenous leukemia and acute lymphoblastic leukemia.
May 27, 2014 /PRNewswire/ -- Decision Resources Group finds that Novartis's Glivec is the clear agent of choice for first-line treatment of chronic myelogenous leukemia (CML) patients in the chronic phase, according to surveyed hematological oncologists from France, Germany, Italy, Spain and the United Kingdom (EU5).

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