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chronic hypoxia

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chronic hypoxia,
a usually slow, insidious reduction in tissue oxygenation resulting from gradually destructive or fibrotic lung diseases, congenital or acquired heart disorders, or chronic blood loss. The patient experiences persistent mental and physical fatigue, shows sluggish mental responses, and complains of a loss of ability to perform physical tasks. Unless treated, the condition may lead to disability. There may be some physiologic adjustment to the lack of oxygen as occurs in individuals who move from sea level to mountainous areas, where oxygen pressures are reduced. Compare acute hypoxia.


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The cumulative effects of repeated exposure to hypoxia has been shown to have population level effects by resulting in differential genetic responses between grass shrimp (Palaemonetes pugio) exposed to chronic hypoxia (1.
However, the effects of chronic hypoxia on vascular stiffening in all three proximal conduit vessels of rats have, to our knowledge, not been previously investigated.
In a study of rats, (9) researchers showed that chronic hypoxia (the same type typically seen in heart disease) induced by decreased blood flow to the brain caused a substantial drop in acetylcholine levels, as well as brain cell damage.
 
 
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