chronic myeloid leukaemia

(redirected from chronic granulocytic leukaemia)

chronic myeloid leukaemia

An indolent leukaemia, characterised by increased mature granulocytes in the peripheral circulation.

Clinical findings
Often asymptomatic; otherwise with splenomegaly, left sided pain, general malaise, joint pain, low-grade fever, pancytopaenia resulting in increased infections, anaemia, thrombocytopaenia.
 
Genetics
Philadelphia chromosome, a fusion gene bcl-abl from a 9:22 translocation, resulting in a gene product with tyrosine kinase activity.

Management
Imatinib mesylate induces major cytogenetic responses in 60% of patients with chronic-phase CML and complete haematologic responses in 95% of CML patients.

chronic myeloid leukaemia

A myeloproliferative disorder caused by a constitutively active BCR-ABL tyrosinase kinase. It has been found that continuous treatment of chronic phase chronic myeloid leukaemia with the drug imatinib can induce durable responses of five years or more in a high proportion of patients
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