Researchers in the Keck School of Medicine of the University of Southern California (USC), together with scientists in Beijing, China, have discovered a chromosomal mutation
responsible for a very rare condition in which people grow excess hair all over their bodies.
Several mutagenicity assays, which detect either large chromosomal mutations
, homologous recombination, or score mutants located on nonessential genes, have demonstrated the mutagenic potential of various fiber types (19-22).
Exceptional chromosomal mutations
in a rodent population are not strongly underdominant.
The dominant mechanisms of fluoroquinolone resistance identified are 1) chromosomal mutations
causing reduced affinity of DNA gyrase and topoisomerase IV for fluoroquinolones and 2) overexpression of endogenous MDR pumps.
Resistance phenotypes have been more thoroughly investigated in Escherichia coli and linked to chromosomal mutations
in the target (murA) or transporter (glpT and uhpT) genes or less frequently to plasmid-mediated fosfomycin resistance genes (fosA, fosB, fosC) encoding glutathione S-transferases that inactivate the drug (4).
Because different forms of cancer are associated with different chromosomal mutations
, we believe analysis of exosome DNA taken from blood samples may not only help determine the presence of a cancerous tumor somewhere in the body, but identify mutations without a need for tumor sample.
In addition to the acquired resistances caused by chromosomal mutations
Kalluri added that because different forms of cancer are associated with different chromosomal mutations
, they believe analysis of exosome DNA taken from blood samples may not only help determine the presence of a cancerous tumour somewhere in the body but also identify mutations without a need for tumour sample.
The PrenaTest is being further developed "to identify other chromosomal mutations
such as Trisomy 13 and 18," said Dr.
During vertical evolution, microbes develop advantageous chromosomal mutations
that they pass on to their progeny.
pallidum chromosomal mutations
associated with azithromycin resistance and treatment failures have been documented in several areas in the United States.
However, there is less direct evidence that illustrates chromosomal mutations
of asbestos fibers in various organs and tissues in intact organisms.