chromosomal breakage

chromosomal breakage

The disruption of a chromosome, as by radiation or toxic chemicals. When this occurs, the two fragments may rejoin, or a fragment may rejoin another broken chromosome. Unrepaired chromosome breaks are associated with many malignant and premalignant conditions.
References in periodicals archive ?
This model allows analysis of pooled data over groups of individuals to establish non-random site-specific chromosomal breakage with respect to total breakage.
New telomere formation after developmentally regulated chromosomal breakage during the process of chromatin diminution in Ascaris lumbricoides.
Effect of oxidants and antioxidants on chromosomal breakage in Fanconi anemia lymphocytes.
The effect of superoxide dismutase, catalase and L-cysteine on spontaneous and mitomycin C induced chromosomal breakage in Fanconi's anemia and normal fibroblasts as measured by the micronucleus method.
The disease carries an increased risk of leukemia and lymphoma, and is one of a small group of inherited diseases in which an abnormal amount of unrepaired chromosomal breakage occurs.
The British group did not find defective DNA ligase I activity in cells from patients with other rare diseases associated with unrepaired chromosomal breakage.
Similarly, this approach established the role of [Beta]-pol in long patch repair and established that the failure of this repair system can lead to chromosomal breakage and apoptosis (15,16).
Multicolour FISH detection if radioactive iodine induced 17ce-p53 chromosomal breakages in buccal cells from therapeutically exposed patients.