chromophobe renal cell carcinoma

chromophobe renal cell carcinoma

a low-grade renal cell carcinoma composed of large polygonal cells with well-defined borders and amphophilic or pale cytoplasm. These cells grow in solid sheets, but focally they may form tubules, trabeculae, or cysts.

chromophobe renal cell carcinoma

An uncommon (4–5% of all renal tumours) renal cell carcinoma with relatively indolent growth and histologic changes of renal oncocytoma. It is thought to arise in the intercalated cells of the collecting ducts.

DiffDx
Oncocytoma, renal cell carcinoma—granular cell type.
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Clear cell, papillary and chromophobe renal cell carcinoma in patients younger than 20 years old: A clinicopathologic study with follow-up.
In a separate presentation, use of Caris Molecular Intelligence led researchers to conclude that chromophobe renal cell carcinoma (chRCC), a rare subtype that accounts for 5% of RCC cases, may be amenable to certain types of chemotherapy, based on the expression (or lack thereof) of various predictive biomarkers.
Chromophobe renal cell carcinoma accounts for approximately 5% of all renal neoplasms and is a distinct subtype of renal cell carcinoma.
Chromophobe renal cell carcinoma (ChRCC) is a variant of parenchymal renal cell carcinoma, comprising 2-5% of all renal cell carcinoma and characterised by unique morphological, histochemical, ultrastructural and genetic features (1-5).
1,4) Renal mass biopsy is the most reliable diagnostic modality, but can be complicated by histopathological similarities between oncocytoma and eosinophilic variants of chromophobe renal cell carcinoma (RCC).
Of the currently recognized renal tumors, 3 types--clear cell renal cell carcinoma (CCRCC), papillary renal cell carcinoma (PRCC), and chromophobe renal cell carcinoma (ChRCC)--account for approximately 90% to 95% of all malignant kidney tumors in adults.
Immunohistochemical analysis of chromophobe renal cell carcinoma, renal oncocytoma, and clear cell carcinoma: an optimal and practical panel for differential diagnosis.
MRI features of renal oncocytoma and chromophobe renal cell carcinoma.
KIT and RCC are useful in distinguishing chromophobe renal cell carcinoma from the granular variant of clear cell renal cell carcinoma.
Diagnostic value of cytokeratin 7 and parvalbumin in differentiating chromophobe renal cell carcinoma from renal oncocytoma.
One of the most common reasons for consultation in renal neoplasia remains the differential diagnosis of renal oncocytoma (RO) and the eosinophilic variant of chromophobe renal cell carcinoma (ChRCC).