chromophobe renal cell carcinoma

chromophobe renal cell carcinoma

a low-grade renal cell carcinoma composed of large polygonal cells with well-defined borders and amphophilic or pale cytoplasm. These cells grow in solid sheets, but focally they may form tubules, trabeculae, or cysts.

chromophobe renal cell carcinoma

An uncommon (4–5% of all renal tumours) renal cell carcinoma with relatively indolent growth and histologic changes of renal oncocytoma. It is thought to arise in the intercalated cells of the collecting ducts.

DiffDx
Oncocytoma, renal cell carcinoma—granular cell type.
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The eosinophilic variant of chromophobe renal cell carcinoma can have a low-power architecture that can closely mimic an oncocytoma, however, often the eosinophilic variant of chromophobe renal cell carcinoma has a more solid and trabecular architecture than a classic oncocytoma.
3) Often times it is difficult to histologically distinguish clear-cell renal cell carcinoma from chromophobe renal cell carcinoma and having the difference in the levels of CB1 receptor, i.
The histopathology was reported as Eosinophilic variant of chromophobe Renal Cell Carcinoma (RCC); pancreatic cytology malignant lesion cannot be ruled out.
Chromophobe renal cell carcinoma (ChRCC) is a variant of parenchymal renal cell carcinoma, comprising 2-5% of all renal cell carcinoma and characterised by unique morphological, histochemical, ultrastructural and genetic features (1-5).
In a study by Zhang J et al1 most common type was Clear cell Renal cell carcinoma followed by papillary renal cell carcinoma and chromophobe renal cell carcinoma.
Utility of cytokeratin 7 for distinguishing chromophobe renal cell carcinoma from renal oncocytoma.
Clear cell, papillary and chromophobe renal cell carcinoma in patients younger than 20 years old: A clinicopathologic study with follow-up.
Immunohistochemical analysis of chromophobe renal cell carcinoma, renal oncocytoma, and clear cell carcinoma: an optimal and practical panel for differential diagnosis.
Chromophobe renal cell carcinoma (ChRCC) is the most-common type of RCC with eosinophilic cytoplasm and the third most-common RCC subtype overall (81,82); it can occur across a large age range but is most frequently seen in relatively older patients, and it usually presents as a large, well-circumscribed, unencapsulated, solid, tan-brown mass with or without a central scar.
1,4) Renal mass biopsy is the most reliable diagnostic modality, but can be complicated by histopathological similarities between oncocytoma and eosinophilic variants of chromophobe renal cell carcinoma (RCC).
5) Other types of nonclear cell renal cell carcinoma metastases that have been described to affect the pancreas include chromophobe renal cell carcinoma.